Alvotech is a global biopharmaceutical company dedicated to become one of the leaders in the biosimilar monoclonal antibody market. Alvotech is an independent sister company of the international pharmaceuticals company Alvogen. The company is headquartered in Reykjavik, Iceland, and has an increasingly global presence and a broad network of partners around the world.
Alvotech has six key biosimilar molecules in development and a new state-of-the-art manufacturing plant for development and commercial supply. Alvotech is investing over $500 million in the development of its pipeline and facility.
Within Alvotech Germany we are currently recruitung a
Scientist Upstream Development (m/f)
At the site in Jülich, Alvotech focuses on process development for its biosimilar pipeline, including cell line development, upstream and downstream processing as well as analytics. You will be part of the upstream development team and take responsibility for development, characterization and validation of manufacturing processes (mainly, but not limited to CHO-S). This includes also activities in media development, scale-up and transfer.
Most important tasks of the job:
Plan, coordinate, execute and evaluate cell culture experiments at different scales (15 ml up to 50 l)
Take part in process characterization and validation projects
Contribute to a successful scale-up and transfer of developed processes
Develop appropriate scale-down models in cooperation with the USP team of the manufacturing site in Iceland
Actively communicate with and support other departments (cell line development, DSP and analytics)
Supervision of lab technicians
Compilation of QA compliant development reports, SOPs and technology transfer documents as needed
Qualification of lab equipment
Presentation of relevant data in internal as well as external meetings
You will be part of the upstream development team and report directly to the department head.
PhD in biochemistry, biotechnology, biology or related with relevant hands-on experience (preferably from industry) in the abovementioned areas and expert knowledge in one of the fields (media/feed development, scale-up, HTP screening, bioreactor control)
Sound knowledge of bioreactor design, control strategies and scale-up principles
Very good scientific understanding of impact of process changes on product quality (mAb)
Experienced in high throughput screening and application of DoE and QbD principles, ideally worked with Ambr15
Broad scientific knowledge and ability to think interdisciplinary
Good presentation and writing skills
very good command of English, German highly beneficial
First management and leadership experience, critical thinking
What we offer:
In response to our innovative and stimulating atmosphere of a multicultural and demanding environment, we offer opportunities to bring forward ideas, lead change as well opportunities for personal development and growth in an international company.
Should you be interested, please send your complete curriculum vitae in English, references (including certificates, both in one pdf - document), salary expectations, and your earliest possible starting date by applying online to Mrs. Iris Landen: email@example.com