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Biology, Chemisty Student for Research Internship - Protein folding in vivo and in vitro (m/f)

We are looking for highly motivated students with majors in molecular biology/genetics/biotechnology/biochemistry/biophysics that are interested in understanding how proteins fold in vivo
Internships in our lab are paid and take 3-12 months. The student can pick the starting date.

Our lab studies protein folding both in the test tube and in the cell. We aim to understand protein folding well enough to be able to manipulate it. We ask organisms themselves to solve protein folding problems. By examining their solutions we can better understand folding in the cell. We have developed folding biosensors that link protein stability to antibiotic resistance. They enable us to optimize folding in vivo (1) and discover new molecular chaperones (2). Protein folding in the cell is intimately tied to the action of folding catalysts and chaperones. We study the action of these folding helpers both in vivo (E. coli and yeast) and in vitro using a wide range of genetic, biochemical, biophysical and structural techniques (2,3,4,5).

We have a lot of experience working with German graduate, master and diploma students and can help with the paperwork. Our lab is located at the University of Michigan, one of top five public schools in the country, which provides an excellent research environment.

1. Foit L et al (2009) Optimizing protein stability in vivo. Mol Cell 36: 861-871.
2. Quan et.al. (2011) Genetic selection designed to stabilize proteins uncovers a 
chaperone called Spy. Nature Struct. Mol. Biol.18(3):262-9
3. Foit L et al. (2011) Chaperone activation by unfolding. PNAS 110(14):E1254-62.
4. Quan S et al. (2014) Super Spy variants implicate flexibility in chaperone action. Elife.3:e01584.
5. Stull F et al. (2016). Substrate protein folds while it is bound to the ATP-independent chaperone Spy. Na.t Struct. Mol. Biol​. 23(1):53-8.

Kontaktdaten


Art des Bewerbungszugangs
Please email CV, current transcript/list of classes taken and contact information for at least two references to James Bardwell (jbardwel@umich.edu).
Kontakt für Bewerbungen
Dr. James C. A. Bardwell
University of Michigan
Department of Molecular, Cellular, and Developmental Biology
Natural Science Building, Room 4007A
830 N. University
Ann Arbor, MI 48109
USA
Phone: +1-734-764-8028
Email: jbardwel@umich.edu

Details der Stellenanzeige


Arbeitszeit
Vollzeit
Vertragslaufzeit
Befristete Anstellung
Stellentyp
Praktikum & Werkstudenten
Berufserfahrung
Berufserfahrung nicht vorausgesetzt
Region
Vereinigte Staaten von Amerika
Arbeitsort
48109 Ann Arbor, MI, USA
Fachgebiet
Biologie & Life Sciences, Chemie
JETZT BEWERBEN