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PhD Position for „The role of ER-resident glycosylation in vertebrate neural development“

 Ruprecht-Karls-Universität Heidelberg  69120 Heidelberg
Within the context of the DFG-funded project FOR 2509 The concert of dolichol-based glycosylation: from molecules to disease models” the research group of Prof. Dr. Joachim Wittbrodt at the Centre for Organismal Studies Heidelberg, Heidelberg University, Germany, is offering

a PhD Position

for the project

The role of ER-resident glycosylation in vertebrate neural development

for an initial period of 3 years.

Payment will be according to the German TV-L13 (part-time).

The position will be available from 1 July 2017.

Project:
The perception of the extracellular environment is of key importance in particular for neural development. Crucial events in neural development e.g. the neural plate patterning, neuroblast differentiation and migration, or axonal outgrowth highly depend on cell-surface interactions to facilitate cell-cell contacts, the adhesion to the cellular matrix or perception of extracellular signals. Extracellular surface proteins are modified by N-glycosylation (N-Glyco) as well as C- and O-mannosylation (O-Man) or combinations of these. These modifications affect protein functionality. Consequently, impaired glycosylation results in to severe defects of brain / neuronal development in human patients / animal models.
Fish models (medaka, Oryzias latipes) offer alternative routes to study glycosylation during neural development. Extrauterine development on the one hand allows the observation of phenotypes from the earliest stages onwards. Mutant cells can also be studied in the context of an otherwise wild type embryo (focusing on the stem cell niche of the eye) by clonal analysis following blastomere transplantation. This allows to overcome early embryonic lethality to study subsequent processes in neural development and growth. This fact, together with modern tools of genome editing (CRISPR/Cas9) facilitate the establishment and detailed molecular and developmental analyses of tractable animal models that closely resemble human syndromes.

Methods that will be used:
Advanced genetics, CRISPR/Cas9, experimental embryology, immunohistochemistry, molecular and cellular biology, advanced imaging

Expected profile of candidate’s qualification:
Molecular and developmental biology, fluent in English, team player, enthusiasm, dedication for basic science

Application process:
Applications including a CV, a brief summary of current and future research plans (1 page max), relevant certificates, and contact details of at least one academic referee should be submitted via email (1 single PDF file) or mail to Ines Petersen (ines.petersen@cos.uni-heidelberg.de), Centre for Organismal Studies Heidelberg, Heidelberg University, Im Neuenheimer Feld 360, 69120 Heidelberg, Germany. We ask for your understanding that applications submitted via mail cannot be returned.

Application deadline is 21 May 2017

As an equal opportunity employer, Heidelberg University actively encourages applications from women. Preference will be given to equally qualified applicants with severe disabilities.
 
How to apply:
Applications including a CV, a brief summary of current and future research plans (1 page max), relevant certificates, and contact details of at least one academic referee should be submitted via email (1 single PDF file) or mail to Ines Petersen (ines.petersen@cos.uni-heidelberg.de), Centre for Organismal Studies Heidelberg, Heidelberg University, Im Neuenheimer Feld 360, 69120 Heidelberg, Germany. We ask for your understanding that applications submitted via mail cannot be returned.
Kontakt für Bewerbungen
For information about the project, please visit our website: https://www.cos.uni-heidelberg.de/index.php/i.petersen/The%20concert%20of%20dolichol-based%20glycosylation:%20from%20molecules%20to%20disease%20models?l=
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