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PhD position in chromatin biology/epigenetics

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Project description:
Gene transcription in eukaryotes takes place in a chromatin context. Therefore, the (re-)organisation of chromatin has profound effects on gene activity and can be influenced by the action of chromatin remodellers.
Our group is interested in how the ISWI family of remodelers influence chromatin structure. The new team member will have the opportunity to study the effect of ISWI remodellers on chromatin dynamics and the production of non-coding RNAs, using yeast as a model system. We use a muti-disciplinary approach, combining in vivo approaches such as yeast genetics, genomics and proteomics, with in vitro biochemistry and computational approaches.
 
The Lab:
The position will be located in the newly opened BioMedical Center (BMC) of the LMU within the biomedical research campus in Munich-Martinsried. The BMC houses a number of internationally competitive groups and state-of-the-art facilities. The Physiological Chemistry Department covers a wide variety of disciplines, including genetics, molecular biology, biochemistry, cell biology, biophysics and structural biology.
 
We are looking for:
  • very good marks in Biochemistry, Biological Sciences or related subjects
  • strong interest in chromatin biology/epigenetics
  • strong interest in analysis of genome-wide data sets
  • good expertise in molecular biology and biochemistry
  • ability to work self-motivatedly in an international team
  • good verbal and written English skills
 
Methods:
This is an interdisciplinary project and involves
  • yeast genetics
  • genomics (ChIP-seq, RNA-seq)
  • molecular biology
  • biochemistry
  • proteomics
 
Start date: 01.12.2016
Duration: The position is initially limited to 1 year and can be extended thereafter.
 
Our previous publications on this topic:
Chromatin remodellers Isw1 and Chd1 maintain chromatin structure during transcription by preventing histone exchange. Smolle et al., Nature Struct Mol Biol 2012, 19:884-892.
 
Set2 methylation of histone H3 lysine 36 suppresses histone exchange on transcribed genes. Venkatesh et al., Nature 2012, 489:452-455.
 
Review articles:
reSETting chromatin during transcription. Smolle et al., Epigenetics 2013, 8:10-15.
 
Transcription-associated histone modifications and cryptic transcription, Smolle & Workman, Biochimica Biophysica Acta 2013, 1829:84-97.
 

Kontaktdaten


Art des Bewerbungszugangs
Please send your application (motivation letter, CV, names of two referees and transcripts in one PDF) until November 4, 2016 by email to michaela.smolle@med.lmu.de
 
Kontakt für Bewerbungen
Prof. Dr. Michaela Smolle
Biomedical Center Munich
Physiological Chemistry
Ludwig-Maximilians-University
Grosshaderner Str. 9
82152 Munich

michaela.smolle@med.lmu.de

Details der Stellenanzeige


Arbeitszeit
Vollzeit
Vertragslaufzeit
Befristete Anstellung
Stellentyp
Promotionsstelle
Berufserfahrung
Berufserfahrung nicht vorausgesetzt
Region
Deutschland (Bayern)
Arbeitsort
82152 Planegg - Martinsried / München
Fachgebiet
Biologie & Life Sciences
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