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PhD position in Chromatin Biology & Proteomics

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In the field of “Deciphering DNA damage signaling using mass spectrometry-based proteomics” the research group of Dr Petra Beli offers the following PhD project:

Understanding ubiquitin signaling in the cellular response to DNA damage

Posttranslational modification of proteins by ubiquitin is an essential mechanism regulating many cellular processes; in particular protein degradation and DNA repair. Ubiquitin ligases catalyze the attachment of the ubiquitin molecules to lysine residues in target proteins and thereby provide the specificity to the ubiquitin system. Mutations in a number of ubiquitin ligases are associated with neurodegenerative diseases or predisposition to the development of malignancies. However, the protein targets and functions of most ubiquitin ligases in human cells remain elusive. We have recently developed mass spectrometric methods to investigate cellular ubiquitylation patterns and employed these methods to study the response of the ubiquitin system to cellular perturbations including proteasome inhibition and genotoxic stress. The aim of this project is to identify protein substrates and functions of selected ubiquitin ligases implicated in DNA damage repair and signaling. To this end, the PhD candidate will employ a range of methods including mass spectrometry-based proteomics, cell biological and biochemical methods (flow cytometry, confocal microscopy, immunoprecipitation) and functional genomics.

We offer

• The possibility to work on a cutting-edge project using state-of-the-art technology in a highly motivated research team
• A stimulating, diverse and international research environment
• Advanced training opportunities
• A fully funded PhD position

Required qualifications

• Master or Diploma
• Motivation to solve complex biological problems
• Excellent communication skills

Starting date: 1 March 2017 or later
Deadline for applications (exclusively online via web form): 10 November 2016


Art des Bewerbungszugangs
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Kontakt für Bewerbungen
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Details der Stellenanzeige

Befristete Anstellung
Berufserfahrung nicht vorausgesetzt
Deutschland (Rheinland-Pfalz)
55128 Mainz
Biologie & Life Sciences