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PhD position in DNA demethylation and development

In the field of “DNA demethylation and development” the research group of Professor Christof Niehrs offers the following PhD project

Developmental epigenetics in Xenopus embryos

In this project we will carry out a screen for novel epigenetic and demethylation regulators in Xenopus (frog) embryos, where microinjection yields facile access to functional analysis of gene function.
We will misexpress candidate epigenetic regulators by mRNA overexpression and antisense Morpholino injection to score for interesting developmental phenotypes. Candidate genes will then be studied by next generation sequencing, including genome-wide gene expression (RNA-seq) to monitor marker gene expression changes and DNA methylation (bisulfite-seq) analysis.  Further characterization of changes in embryonic gene expression will be followed up by genome wide ChIP-seq and bioinformatics analysis.  We will employ a systems biology approach for the understanding of the candidates gene function.

We offer

• The possibility to work on a cutting-edge project using state-of-the-art technology in a highly motivated research team
• A stimulating, diverse and international research environment
• Advanced training opportunities
• A fully funded PhD position

Required qualifications

• Master or Diploma
• Motivation to solve complex biological problems
• Excellent communication skills

Starting date: 1 March 2017 or later
Deadline for applications (exclusively online via web form): 10 November 2016


Art des Bewerbungszugangs
Please apply exclusively online via our web forms:
Kontakt für Bewerbungen
Please see  our website:

Details der Stellenanzeige

Befristete Anstellung
Berufserfahrung nicht vorausgesetzt
Deutschland (Rheinland-Pfalz)
55128 Mainz
Biologie & Life Sciences