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PhD position in Molecular Biology - Protein-RNA interactions

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In the field of “Genomic views of protein-RNA interactions and splicing regulation” the research group of Dr. Julian König offers the following PhD project:
Computational approaches towards cracking the splicing code
Description:
The regulation of splicing is achieved through the coordinated binding of many RNA-binding proteins. It is becoming clear that their recruitment is not solely dependent on the underlying RNA sequence, but is strongly shaped by the interactive environment. Means of interaction include direct competition, cooperative recruitment and the modulation of secondary structure. Knowledge about the acting forces is therefore critical to predict the function of an RNA-binding protein and its impact on the splicing outcome. 
This project aims at a global understanding of RBP interactions in the context of splicing regulation. The PhD student will develop and apply computational tools to investigate first-hand genome-wide datasets that were generated with state-of-the-art techniques such as RNA-seq and iCLIP. The data will be integrated using network analyses and machine learning strategies to obtain systemic views on the combinatorial action of RBPs in splicing regulation. The project will be based on close collaborations with experimental and computational scientists within and outside our group.
We offer
•          The possibility to work on a cutting-edge project using state-of-the-art technology in a highly motivated research team
•          A stimulating, diverse and international research environment
•          Advanced training opportunities
•          A competitive stipend
 
Required qualifications
•           Master or Diploma
•           Motivation to solve complex biological problems
•           Excellent communication skills
 
Starting date: 1 September 2016 or later
Duration of stipend: 3 years, with the possibility of extension
Deadline for applications (exclusively online via web form): 1 May 2016
 

Kontaktdaten


Art des Bewerbungszugangs
Please apply exclusively via our online form at:

https://www.imb-mainz.de/students-postdocs/international-phd-programme/apply-to-ipp/
Kontakt für Bewerbungen
For further questions and contact information please check our website:

http://www.imb.de/PhD

Details der Stellenanzeige


Arbeitszeit
Vollzeit
Vertragslaufzeit
Befristete Anstellung
Stellentyp
Promotionsstelle
Berufserfahrung
Berufserfahrung nicht vorausgesetzt
Region
Deutschland (Rheinland-Pfalz)
Arbeitsort
55128 Mainz
Fachgebiet
Biologie & Life Sciences