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PhD position in Quantitative proteomics to study gene regulation

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In the field of “Quantitative proteomics to study gene regulation” the research group of Dr Falk Butter offers the following PhD project:

Proteomic analysis of gene regulation in C. elegans

The nematode C. elegans is a classical model organism in development and ageing research. In this project we aim to understand developmental posttranscriptional regulation in C.elegans using the combination of classical molecular biology techniques (cloning, protein expression) and proteomics to investigate the regulation of RNA-binding proteins during development. To this end, we will utilize our RNA-protein interactome approach to characterize the RBPome in C.elegans, expecting to uncover several new RNA-binding proteins. In the second step, we will proceed to investigate the dynamic recruitment of RNA-binding proteins during the life span of the worm to uncover developmentally regulated proteins that will in a third step be studied for their functional influence in development and ageing. Here, we will closely collaborate with the Ketting group at IMB using transgenic strains, RNAi, gene-editing techniques, and other assays.

We are looking for a motivated student interested in working at the bench, but also keen to master the bioinformatics skills required by –omics approaches. Ability to work independently and experience in standard molecular biology techniques is necessary. Previous exposure to large scale data analysis is a plus, but not a requirement. Due to the collaborative nature of proteomics, the interest in collaborations beyond the direct research project is expected.

We offer
• The possibility to work on a cutting-edge project using state-of-the-art technology in a highly motivated research team
• A stimulating, diverse and international research environment
• Advanced training opportunities
• A fully funded PhD position

Required qualifications
• Master or Diploma
• Motivation to solve complex biological problems
• Excellent communication skills

Starting date: 1 March 2017 or later
Deadline for applications (exclusively online via web form): 10 November 2016


Art des Bewerbungszugangs
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Kontakt für Bewerbungen
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Details der Stellenanzeige

Befristete Anstellung
Berufserfahrung nicht vorausgesetzt
Deutschland (Rheinland-Pfalz)
55128 Mainz
Biologie & Life Sciences