PhD Position Molecular Virology
The major focus of the group is on unraveling molecular mechanisms by which measles virus (MV) suppresses T cell activation.
Exploring a new area of research, we focus on the role of membrane lipids (sphingolipids) in T cell activation. We found that MV perturbs membrane dynamics to interfere with T cell activation. Our data show that components essential for T cell receptor signaling relay are subject to membrane lipid mediated regulation and this is affected by MV (Gassert et al., Plos Path, 2009; Müller et al., Plos Path, 2014). More recently, we established the role of dynamic alterations of the sphingolipid pathway in the metabolic reprogramming of T cells, which is essential for their activation and effector functions. Following those observations, the goal of the PhD project is to identify molecular targets and mechanisms of metabolic reprogramming and interference of MV with this pathway.
The project is embedded into the DFG Research Unit 2123 “Sphingolipid dynamics in infection control” (www.virologie.uni-wuerzburg.de/for2123). It is therefore not only very exiting by itself, but in addition offers interaction with ten collaborating research groups in this consortium and access to their collection of unique tools, analytics and protocols. Furthermore the doctoral researcher will become part of the Graduate School of Life Sciences at the University of Würzburg (www.graduateschools.uni-wuerzburg.de/life_sciences) offering a strong peer network and a wide variety of research training and career development opportunities.
Applicants must hold a master’s degree in biology, biomedicine, biochemistry or a related discipline. The University of Würzburg is an equal opportunities employer and places particular emphasis on fostering career opportunities for women, who are strongly encouraged to apply. Applications of disabled persons with equal qualifications will be treated preferentially.
Please send your applications by e-mail to:
Prof. Sibylle Schneider-Schaulies
Please submit the following documents combined in one single PDF file (only complete applications will be considered):
- Motivation letter
- Detailed curriculum vitae
- Description of research experience including applied methodologies
- University diplomas and transcripts
- List of two references with complete contact details (including Master thesis supervisor)
Bitte beziehen Sie sich bei Ihrer Bewerbung auf jobvector und geben Sie die folgende Referenznummer an: GSLS 2016-11/1
Details der Stellenanzeige
Über University of Würzburg, Graduate School of Life Sciences
The Graduate School of Life Sciences (GSLS) Interdisciplinary research training is the key to the success of tomorrow's life scientists. The University of Würzburg provides for a world class environment of research institutions , which have a long standing and successful tradition of co-operation across faculties. The GSLS results from a common initiative of the Faculties...Mehr über die University of Würzburg, Graduate School of Life Sciences