Postdoc "Combined high end imaging technologies for nanoscale investigation of cellular signalling pathways"
Project description:Cells continuously communicate with the surrounding environment employing a variety of signalling molecules and pathways to integrate and transport information. This initializes enzymatic reactions and structural rearrangements leading to the formation of multimolecular signalling complexes responsible for the regulation and progress of signal transduction. A variety of microscopy techniques offer insight onto these type of rearrangements. In this project we use different imaging modalities TIRF, STORM, LSCM and lifetime imaging to investigate the role of individual components of these phenomena at the plasma membrane, inducing activation or resting state via careful design and control of the surfaces the cells interact with.
The Toolbox is a research and support structure of the BIOSS Excellence Cluster of the University of Freiburg. The facility hosts a series of high end microscopes.
Being fully integrated in the Toolbox research structure, the successful candidate is required to conduct original research as an independent postdoc, with the possibility of developing collaborations within the extended network of BIOSS groups.
- PhD degree in life sciences or related field
- Experience using light and/or electron microscopy in order to answer biological questions
- Strong interpersonal skills to work with multiple users; service-oriented spirit
- Experience in live cell imaging, cell culture and molecular biology
- Strong motivation to implement new techniques in the facility
- Proficiency in English
- Training and/or teaching experience
- Experience in EM sample preparation using cryofixation and cryoultramicrotomy
- Experience in fluorescence superresolution
- Experience in image analysis
Contract type: full time, 10 months maternity cover, starting in December 2016.
If you are interested in applying for this role, please submit your CV and covering letter, explaining your motivation and suitability for this role, to Giulia.email@example.com.
Deadline for applications is 28.10.2016
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Über Universität Freiburg
Biological signalling processes are the key regulators of cellular activity in all types of cells in living organisms. A better understanding of these processes not only provides solutions to important biological problems, but also has a major impact on medical research and practice. The Centre for Biological Signalling Studies (BIOSS) in Freiburg uses modern analytical methods and strategies...Mehr über die Universität Freiburg