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Doctoral Researcher Position: Immune evasion of clinical pneumococcal isolates derived from infant patients with the kidney disease hemolytic uremic syndrome

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The Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute – in cooperation with the Friedrich Schiller University, the University Hospital Jena and the Max Planck Institute for Chemical Ecology are offering an international graduate training programme. The
 
International Leibniz Research School (ILRS Jena)
 
gives doctoral researchers the possibility to prepare for their PhD exam in an ambitious program providing excellent research conditions. We invite applications for a
 
Doctoral Researcher Position (Ref. No. ILRS_04/2016)
Immune evasion of clinical pneumococcal isolates derived from infant patients with the kidney disease hemolytic uremic syndrome
 
The Department of Infection Biology at the Leibniz Institute for Natural Product Research and Infection Biology is interested to understand the immune evasions strategies of human pathogenic microbes, in particular how microbial pathogens control host complement attack, how they modulate inflammation and how pathogens modulate the response of innate immune effector cells. Such evasion strategies are characterized by multiplicity and redundancy. Streptococcus pneumoniae is a human respiratory pathogen that causes invasive and mucosal diseases and is also associated with hemolytic uremic syndrome (HUS), a severe human kidney disease.
In order to define the immune evasion strategies of this pathogenic Gram positive bacterium in detail, we characterize the pneumococcal moonlighting proteins PspC (pneumococcal surface protein C) and Tuf (translation elongation factor Tu). We are interested in identifying the repertoire of host proteins that are bound by the two pneumococcal proteins, in identifying new ligands and in defining how host regulators attached to the bacterial surface assist the bacterium in immune evasion. The characterization of the clinical pneumococcal isolates derived from infant HUS patients is aiming to define how the microbial pathogens contribute to disease pathogenesis and to endothelial damage in the microvasculature. The clinical pneumococcal isolates derived from infants with HUS bind human immune regulators Factor H and plasminogen with higher intensity as the reference strain D39. We postulate these clinical isolates express unique PspC and Tuf variants and therefore aim to clone the corresponding proteins and analyze how such new variants control virulence and bacterial immune evasion and how they lead to disease pathology and ultimately to kidney damage.

We expect:
  • a Master’s degree (or equivalent allowing you to pursue a PhD degree) in Natural or Life Sciences. Research at ILRS is centred around “Microbial and Biomolecular Interactions”. Candidates about to earn their degree are welcome to apply.
  • high motivation and interest to join one of the research areas of ILRS
  • creativity and interest in shaping your own thesis project
  • an integrative and cooperative personality with enthusiasm for actively participating in our lively community
  • very good communication skills in English
  • experience in microbiology, immunobiology and moleclaur biology is required
We offer:
  • a top-level research environment
  • efficient supervision by a team of advisors
  • a comprehensive mentoring programme
  • courses in state-of-the-art technologies and soft skills
  • strong communication and interaction between the involved institutions
  • Jena – City of Science: innovative business activities, successful scientific centres and a vibrant cultural scene around the famous Friedrich Schiller University
The three-year Doctoral Researcher position is available starting from July 2016. Salary will be paid according to TV-L (salary agreement for public service employees). HKI is an equal opportunity employer.

Further information:
Prof. Dr. Peter F. Zipfel, PI, peter.zipfel@leibniz-hki.de
Dr. Christine Vogler, ILRS Coordinator, ilrs@leibniz-hki.de

The application process is handled exclusively online. Please acquaint yourself with the scientific projects offered on our website and thoroughly follow the instructions for the online application process:
 
www.ilrs.de/vacant-projects.html

Deadline for application: Apr 14, 2016.
Successful applicants will be invited to attend a recruitment meeting in Jena (envisaged date: Jun 09-10, 2016).

Kontaktdaten


Art des Bewerbungszugangs
The application process is handled exclusively online. Please acquaint yourself with the scientific projects offered on our website and thoroughly follow the instructions for the online application process:
www.ilrs.de/vacant-projects.html

Online Application at: https://www.uni-jena.de/jsmc_online_application/
 
Kontakt für Bewerbungen
Dr. Christine Vogler, ILRS Coordinator, ilrs@leibniz-hki.de

Details der Stellenanzeige


Arbeitszeit
Vollzeit
Vertragslaufzeit
Befristete Anstellung
Stellentyp
Promotionsstelle
Berufserfahrung
Berufserfahrung nicht vorausgesetzt
Region
Deutschland (Thüringen)
Arbeitsort
07745 Jena
Fachgebiet
Biologie & Life Sciences, Biotechnologie