Doctoral thesis at the LMU Munich: Genetic analysis of the AP4 transcription factor in mouse models
Our group is focusing on the control of metastasis-related processes by transcription factors and microRNAs, with an emphasis on p53 and c-MYC regulated pathways. In the past we have described AP4 as a c-MYC-regulated transcription factor which is associated with poor survival and metastasis of colorectal cancer (Jackstadt et al. Journal of Experimental Medicine 2013; Oncotarget 2014; Cell Death&Disease 2014; Jung et al. PNAS 2008).
In the planned project next-generation sequencing approaches and the analysis of genetically engineered mouse models of cancer will be used to elucidate the role and functions of AP4 down-stream of the proto-typic oncogene c-MYC. Candidates should ideally already have experience in working with genetically modified mice.
For more information see:
Prof. Heiko Hermeking
Bitte beziehen Sie sich bei Ihrer Bewerbung auf jobvector
Experimental and Molecular Pathology
Institute of Pathology
Thalkirchner Str. 36
D-80337 Munich, Germany
Tel.: ++ 49-89-2180-73685
Fax: ++ 49-89-2180-73697
Details der Stellenanzeige
Über Ludwig-Maximilians-Universität München
The LMU and its Medical Faculty have established services and programs for young investigators. The Graduate Center of the LMU is a central support unit for doctoral students and coordinates the Academic Career Program, the Doctoral Research Program, and the Doctoral Exchange Program. The Medical Faculty participates in the structural doctoral programs of six Graduate Schools, two of which...Mehr über die Ludwig-Maximilians-Universität München