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Intracellular lifestyle of Salmonella enterica

October, 2016
The Division of Microbiology at the University Osnabrück opens a position on:
Intracellular lifestyle of Salmonella enterica
Applications on are invited for a PhD project investigating the interaction of Salmonella enterica with mammalian host cells with focus on the intracellular lifestyle inside cells. A position for a postgraduate scientist (pay scale E13, 50-65 %) is immediately available for an initial period of 2 years. An extension is anticipated.
Our group is interested in understanding the molecular and cellular basis of bacterial pathogenesis. Of particular interest are the virulence functions of Salmonella enterica required of survival and replication within the Salmonella -containing vacuole (SCV) in host cells. We investigate the environmental signals sensed and responded to by S. enterica in the SCV, and specific defense mechanisms activated by Salmonella . The project involves analyses of the proteome of Salmonella in the SCV, as well as of proteomes of the SCV. We have recently identified a group of host cell proteins that are required for intracellular pathogenesis of Salmonella . The project should lead to a detailed molecular and functional characterization of these host proteins in Salmonella pathogenesis.
Candidates should have a strong background in cell biology and/or microbiology. Working experience in standard and advanced microscopy techniques and in microbiology will be of advantage.
The Division of Microbiology operates several light microscopy systems providing wide-field, CLSM, spinning disk, TIRF, FRAP techniques with live cell environment, and micromanipulation under S2/BL2 conditions. Further microscopy techniques such as F-PALM, TEM and AFM are locally available within the framework of DFG collaborative research center SFB 944, institutional infrastructure and intramural collaborations.
The University Osnabrück offers structured study programs for postgraduate candidates, such as the integrated graduate school of SFB 944 ‘Physiology and dynamics of cellular microcompartments’.


Art des Bewerbungszugangs
Applications should include CV, academic degrees, description of previous research projects, and addresses of at least two referees. Applications and inquiries should be submitted by E-mail to:
Kontakt für Bewerbungen
Prof. Dr. Michael Hensel
Universität Osnabrück, Abt. Mikrobiologie
Fachbereich Biologie/Chemie
Barbarastraße 11
49076 Osnabrück

Details der Stellenanzeige

Befristete Anstellung
Berufserfahrung nicht vorausgesetzt
Deutschland (Niedersachsen)
49076 Osnabrück
Biologie & Life Sciences