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Phd oosition in Cellular Toxicology

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The Leibniz Research Centre for Working Environment and Human Factors (IfADo) at the University of Dortmund integrates both basic and applied science in its mission to understand human health and disease.  Our strength is in our diversity as scientists from different academic backgrounds work together to address specific questions in the areas of liver and metabolic diseases, cancer development and progression, and stress and aging. The successful candidate will join an interdisciplinary network of molecular biologists, immunologists, bioinformaticians, systems biologists and physicians. Our group has a strong background in imaging with several possibilities for microscopy-based analyses. We also have ongoing collaborations for metabolic and lipid analyses.
The research group Cellular Toxicology at IfADo is currently accepting applications for a

PhD student

The position is offered within a newly DFG funded Project “Characterising a role for EDI3 in metastasis in vivo” and is funded for 3 years.
Project description:
Our previous work led to the identification of a protein named EDI3 (GPCPD1; GDE5), which we showed to be involved in both choline and glycerophospholipid metabolism. Both have been reported to be altered in different cancers and metabolic diseases. High EDI3 was found to be associated with metastasis and worse prognosis in endometrial cancer. Using different cancer cell lines and in vitro assays, we have also shown that EDI3 is important for cell migration, adhesion and spreading – phenotypes generally altered in cancer. The proposed project is aimed at understanding the possible role for EDI3 in tumour growth and metastasis using orthotopic and spontaneous metastasis models of cancer in mice. Additionally, further basic characterization of EDI3 will be performed to understand its regulation and function in cells. A detailed description of the project is available upon request.
Requirements:
We are looking for a highly motivated PhD candidate who is not afraid of a challenge and is excited about learning. The candidate should have successfully completed a Master’s degree or diploma/state examination in Molecular Biology, Biochemistry, Biotechnology, Biology Pharmacy or related disciplines with an excellent closing grade. Basic training in cell culture, protein biochemistry, and molecular biology techniques is desirable, and the candidate must be willing to work with animals. The enthusiastic and ambitious candidate should be able to work independently and responsibly, and be willing to establish new techniques/technologies. In return, the candidate will be mentored and supported throughout the thesis work, be included into a group regularly publishing in high ranking journals, integrated into international research networks, and will be able to present their work at national and international meetings. 

Kontaktdaten


Art des Bewerbungszugangs
 Applications should include a CV, letter of motivation, copy of graduation certificates (university), and contact information for two referees. The working language and the language of the doctoral thesis will be English. Candidates planning a research/academic career are particularly welcome.
IfADo is an equal opportunity employer, and does not discriminate on gender, race, colour, religion, national origin, disability, or age in its programs and activities. 
 
Kontakt für Bewerbungen
The position is immediately available. Please send your application per e-mail to Rosemarie Marchan (marchan@ifado.de) or Silke Hankinson (hankinson@ifado.de) by May 30th.
Alternatively, please mail your application to:
Leibniz-Institut für Arbeitsforschung
an der TU Dortmund (IfADo)
Dr. Rosemarie Marchan
Ardeystr. 67
D-44139 Dortmund
Germany
 

Details der Stellenanzeige


Arbeitszeit
Teilzeit
Vertragslaufzeit
Befristete Anstellung
Stellentyp
Promotionsstelle
Berufserfahrung
Berufserfahrung vorausgesetzt
Region
Deutschland (Nordrhein-Westfalen)
Arbeitsort
44139 Dortmund
Fachgebiet
Biologie & Life Sciences
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