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PhD Position in Biochemistry: Molecular Mechanisms of Cdk4 Inhibitor Resistance

Drug resistance is one of the biggest challenges in today’s cancer treatment. An initially effective drug loses its efficacy due to the selection of drug resistant cell populations, leading to malignant relapse and the lack of treatment options. Up until today, the comprehensive identification of drug resistance has been elusive. To address this issue, we employ a broad range of cutting edge technologies, e.g. CRISPR/Cas9-mediated genome wide screens, CRISPR/Cas9/rAAV-mediated gene editing, microscopy, proteomics, cell and molecular biology. To intensify our efforts, we are seeking 2 outstanding and ambitious PhD candidates with a strong background in cell and molecular biology that employ a fundamental interest in logical, systematic and functional analysis of various experimental situations. This multidisciplinary setting, in conjunction with our commitment to mentoring, provides an excellent training opportunity in a young, visionary, international and dynamic research team with interests in fundamental and translational science. The positions can be filled as early as January 2016, set to last 4 years and are directly funded by the Institute of Biochemistry II.
Applications of women are specifically invited. In the case of equal qualifications, competence, and specific achievements, women will be considered on preferential terms within the framework of the legal possibilities. The Goethe University is committed to give preference to handicapped candidates with equivalent qualifications. The limitation of the contract is based upon the regulations of the “Wissenschaftszeitvertragsgesetz” in conjunction with the “Hessischen Hochschulgesetz”. The position will be paid as stipend according to current DFG standards (
Formal applications including a single page description of research interests, CV, grades and the names and contact details of two referees should be addressed directly to: Dr. Manuel Kaulich.


Art des Bewerbungszugangs
Bitte nutzen Sie zur Bewerbung das JobVector-Portal oder kontaktieren Sie mich direkt mit der Zugabe der Referenznummer: JV-MK-IBC2-001.
Kontakt für Bewerbungen
Manuel Kaulich, PhD
Group Leader

Phone: +49 69 6301 5450

Details der Stellenanzeige

Befristete Anstellung
Berufserfahrung nicht vorausgesetzt
Deutschland (Hessen)
60590 Frankfurt am Main
Biologie & Life Sciences