PhD Position in Life Sciences
The mitochondrial protein sorting machinery as molecular target for treatment of
Mitochondria synthesize the vast majority of cellular ATP via oxidative phosphorylation (OXPHOS). Many proteins involved in this fundamental energy-converting process are encoded by nuclear genes and imported into mitochondria after synthesis in the cytosol. The presequence translocase (TIM23) is the major protein import and sorting machinery of the inner mitochondrial membrane. TIM23 mediates both, ATP-driven import of soluble proteins into the matrix and membrane-potential-driven integration of hydrophobic proteins into the inner membrane. We recently demonstrated that genetic and pharmacological modulation of specific TIM23 activities improves the survival of ATP synthase-defective yeast and human cells. In this project, we will employ diverse biochemical, genetic, and cell biological methods to analyze the molecular mechanisms underlying this unexpected rescue and test its general applicability in different models of OXPHOS-deficiency disorders.
The program includes a 6-months stay in a lab of our Canadian partners and offers excellent scientific and transferable skills training at all participating locations. The program language is English and there are no tuition fees. The successful candidate will receive a contract (65% TVL13), as well as support with administrative matters, accommodation, visas etc. We invite applications from highly qualified and motivated students of any nationality and we are looking forward to your application for the PhD fellowship in our group.
Please only use our online application form ( http://www.irtg1830.com/application/ ).
Bitte beziehen Sie sich bei Ihrer Bewerbung auf jobvector und geben Sie die folgende Referenznummer an: IRTG1830-Biochemistry
Department of Plant Physiology
Faculty of Biology
University of Kaiserslautern
Phone: + 49 (0)631-205-3633
Fax: +49 (0)631-205-2600
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Über IRTG 1830
Dysfunction of membrane proteins and of protein compartmentalization can seriously compromise normal functioning of cells and organs, and has been implicated in detrimental diseases. Moreover, altered activity of many membrane proteins causes dramatic effects on developmental and cellular adaptation processes in animal and plant cells. The IRTG 1830 aims to investigate selected membrane...Mehr über die IRTG 1830