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PhD position in Protein Biochemistry

Our lab for Synthetic Biochemistry at the Technische Universität München, Department of Chemistry offers a PhD position in the field of protein biochemistry.
The lab is conducting research in the interdisciplinary area of chemical biology, applying concepts from organic chemistry to develop new chemical tools for the investigation of biological problems. In particular we apply and extend genetic code expansion approaches to incorporate unnatural amino acids with new reactivity site-specifically into proteins.
The PhD project will be positioned at the intersection of protein biochemistry and chemical biology and will deal with the development of proximity enhanced reactions to stabilize transient protein-protein interactions. In particular the PhD student will incorporate unnatural amino acids with reactive moieties via genetic code expansion site-specifically into proteins. Thus modified proteins will be used to elucidate and study protein-protein interactions both in vitro and in vivo. (See Lang et al. Nature Chem. 2012, 5, 298, Lang et al. JACS 2012, 134, 10317, Lang and Chin, Chem. Rev. 2014, 114, 4764).
At the end of their PhD, the candidate will have developed an extensive skillset encompassing theoretical and practical expertise in state of the art chemical biology and molecular biology expertise.
Candidates should hold a Master’s degree in Biochemistry with a strong background and solid hands-on experience in standard molecular biology techniques and protein biochemistry (molecular cloning techniques, protein expression and purification). Knowledge and practical experience in organic chemistry will be beneficial. A strong interest in chemical biology oriented research is also essential.
The application should include a letter of motivation, a CV with two references, transcripts of academic records and a short summary of your Master thesis.
contact: Prof. Dr. Kathrin Lang (kathrin.lang@tum.de)
more information: www.synbio.ch.tum.de
How to apply:
Please send your application to kathrin.lang@tum.de
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