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PhD Project "Differential instruction of Th2 cells during nematode and tick infections"

 Freie Universität Berlin  Berlin
The DFG Research Training Group 2046 “Parasite Infections: From Experimental Models to Natural Systems” offers a cutting edge PhD research project on “One Health“ aspects of Parasite Infections.
PhD students will study different parasite infections from the biological, medical, and translational perspectives. In an interdisciplinary approach, graduates will be trained in molecular approaches, cellular interactions and organismic studies on key parasites of model organisms, free-ranging animals and humans.
PhD Project "Differential instruction of Th2 cells during nematode and tick infections"
Institution: Institute of Immunology, Freie Universität Berlin
Centre for Infection Medicine
Freie Universität Berlin
Robert-von-Ostertagstr. 7-13, 14163 Berlin
Supervisor: Dr. Sebastian Rausch and Prof. Dr. Susanne Hartmann
Project Description:
Infections with parasitic nematodes and ticks induce strong local and systemic T helper type 2 (Th2) responses. Dendritic cells are central for the imprinting of the Th2 response in both infections, but innate Th2-associated cells such as mast cells and eosinophils are involved in instructing and regulating Th2 immune responses to nematodes. The aim of this project is to investigate whether mucosal/dermal mast cells and eosinophils affect the quality and homing capacity of Th cells imprinted by local DC populations in infections with the murine gut nematode Heligmosmoides polygyrus and the European tick Ixodes ricinus. Furthermore, the stability of migration patterns of parasite-specific Th2 cells will be assessed in nematode/tick co-infections.
Start: as soon as possible
Application Deadline: July 31, 2015
Further information and application instructions:
How to apply:
You can only apply by using the application form available here: http://www.vetmed.fu-berlin.de/grk204
Kontakt für Bewerbungen
Dr. Juliane Kofer

Freie Universität Berlin
Fachbereich Veterinärmedizin
Institut für Immunologie
Robert von Ostertag-Haus - Zentrum für Infektionsmedizin
Robert-von-Ostertag-Str. 7-13 (Haus 35)
14163 Berlin
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