The Institute of Experimental Musculoskeletal Medicine is seeking a
Subject Biology, Biochemistry, Human Medicine or Life Sciences
Part-time (25 hours/week)
Salary according to TV-L E13 (65 %)
We are seeking a highly motivated PhD Student to join our research group to work on the research project titled “Mechanosensitive signalling complexes as early-stage therapeutic targets in post-traumatic Osteoarthritis (OA)“ funded by the Federal Ministry of Education and Research (BMBF). The position is available to start at the earliest possible opportunity, and is currently funded until 31.01.2019.
A main goal of our institute is to understand the basic mechanisms underlying the development of osteoarthritis and the onset of articular cartilage breakdown. Specifically, this project will focus on the role of mechanosensitive TRPC calcium channels in articular cartilage homeostasis and will use both gain and loss of function approaches to address the functional roles of TRPC channels in chondrocytes in vitro and in vivo and to investigate whether they can be targeted therapeutically in order to prevent osteoarthritis progression.
The PhD project will involve the use of a wide range of experimental techniques including molecular biological (Western blot, siRNA, RT-PCR), histological (tissue histology, immunocyto- and immunohistochemistry,) and cell biological and in vitro assays (chondrogenesis, calcium mobilisation measurement, cell migration) and research using various knock out and transgenic mouse models.
We are seeking an ambitious, highly qualified and motivated student with a strong interest in biomedical research, who should be committed to the advancement of the project and aiming towards developing an academic career. We expect the successful candidate to hold a Master’s Degree in biology, biochemistry or life sciences and to demonstrate prior knowledge and experience of the aforementioned techniques. The ability to both work independently and to contribute effectively to group projects, as well as an excellent command of IT and of the English language are part of the basic prerequisites.
We offer an international scientific community and access to state-of-art research facilities and laboratory equipment. Attending weekly seminars, lectures and project meetings as well as the possibility to participate in national and international conferences and workshops form part of our PhD programme.
Echtermeyer F, Bertrand J, Dreier R, Meinecke I, Neugebauer K, Fuerst M, Lee J, Song YW, Herzog C, Theilmeier G, Pap T (2009) Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis. Nat Med. 15:1072-1076.
Nalesso G, Sherwood J, Bertrand J, Pap T, Ramachandran M, De Bari C, Pitzalis C, Dell’Accio F (2011) WNT-3A modulates articular chondrodyte phenotype by activating both canonical and non canonical pathways. J Cell Biol., 193:551-64.
Sherwood J, Bertrand J, Nalesso G, Poulet B, Pisillides A, Brandolini L, Karystinou A, De Bari C, Luyten FP, Pitzalis C, Pap T, Dell’Accio F (2014) A homeostatic function of CXCR2 signalling in articular cartilage. Ann Rheum Dis. 74(12):2207-15.
Informal inquiries to: Dr. Joanna Sherwood (email@example.com ) or to Prof. Dr. med. Thomas Pap (firstname.lastname@example.org).
Applications from female candidates are particularly encouraged. In the case of equal qualifications, competence and specific achievements, women will be considered on preferential terms within the framework of the legal possibilities unless reasons specific to an individual male candidate predominate. Handicapped candidates with equal qualifications will be given preference.
Formal applications may be sent until 16.03.2016
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