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PhD Student Position: Quantitative live cell single molecule imaging

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The Laboratory for Molecular Imaging (Group leader: Dr. Maximilian Ulbrich) at the BIOSS Centre for Biological Signalling Studies of the University of Freiburg invites applications for a
PhD Student Position
“New labeling strategies for quantitative single molecule imaging of membrane proteins”

The complex rules that govern the assembly of neurotransmitter receptors in synapses provide the molecular basis for the diverse functional repertoire of nerve cells. We recently developed a single molecule based imaging approach to decipher the composition of these receptors with unmatched precision. However, the availability of suitable fluorescent protein markers currently restricts the number of useable colors to two. The goal of this project is to develop novel approaches to utilize the potential of organic dye markers for imaging three or more colors simultaneously. The newly established labeling strategies will not only be applied to resolve the composition of membrane proteins, but also for other single molecule methods like superresolution imaging.

The work in the Ulbrich laboratory includes wet lab biology (cloning, biochemistry, cell culture), instrumentation (assembly of custom single-molecule microscopes), and programming to control equipment and evaluate results. Ideally, applicants should bring enthusiasm for science, creativity, technical and programming skills, as well as experience in microscopy, molecular biology and/or biochemistry. Ph. D. candidates should be independent and motivated individuals who hold a Diploma or M.Sc. degree in Biology, Physics, Chemistry or a related discipline.

The project is initially funded for 3 years by the German Research Foundation DFG but can be extended if required. Please include a CV with a cover letter, the names of at least two references and a statement of research interests that makes clear the motivation to pursue the PhD in the Ulbrich Laboratory. Please submit your application electronically as a single pdf file to:


Art des Bewerbungszugangs
Please send a single pdf file per email.
Kontakt für Bewerbungen
Dr. Maximilian Ulbrich
University of Freiburg
BIOSS Centre for Biological Signalling Studies

Details der Stellenanzeige

Vollzeit oder Teilzeit
Befristete Anstellung
Berufserfahrung nicht vorausgesetzt
Deutschland (Baden-Württemberg)
79104 Freiburg
Biologie & Life Sciences, Physik