PhD Thesis in cancer research/cell biology: Molecular mechanisms of genome dynamics in human cancer cells
Perpetual chromosome missegregation constituting the chromosomal instability (CIN) phenotype is a major hallmark of human cancer and causes the generation of highly aneuploid cancer cells. It is well known that CIN is closely associated with tumorigenesis, tumor progression and therapy resistance. However, the molecular causes leading to chromosome missegregation during mitosis are still little understood. Moreover, the cellular consequences arising from CIN and aneuploidy are also largely unknown. However, it might be conceivable that ongoing genome alterations can drive adaptation processes of tumor cells and thereby contributes to tumor evolution and the development of aggressive tumor phenotypes including therapy resistance.
Our lab has a long-standing expertise in the analyses of genome dynamics and the investigation of chromosome missegregation in human cancer cells.
Examples of our previous work (pfds are available upon request):
Stolz et al., Nature Cell Biology 2010
Ertych et al., Nature Cell Biology 2014
Lüddecke et al., Oncogene 2015
Stolz et al., Cell Cycle 2015
Stolz et al. EMBO Reports 2015
Ertych et al. PNAS 2016, in press.
In the planned project we aim to unravel the role of chromosomal instability and ongoing chromosome missegregation in the adaptation of cancer cells. The planned project will address how chromosome missegregation can contribute to stress responses and to the development of therapy resistance. Here, we are mostly interest in the underlying molecular mechanisms, which will be mainly addressed in various human cell systems. In addition, we aim to investigate the role of stress conditions on the genome evolution. The key question to be addressed is: can stress situations, which are typically found in human tumors, itself trigger genome alterations?
The planed investigations will require the use of state-of-the-art cell biological and molecular biology methods including cell cycle analyses (FACS), fluorescence microscopy, live cell imaging (DeltaVision microscope) etc. Further details about our method repertoire can be found in our most recent publications.
We are specifically looking for a highly motivated and enthusiastic candidate (m/f) with great interest in research on one of the most important phenotypes of cancer cells. The candidate will hold a very good Master degree in Molecular Medicine, Human Biology, Biology, Biochemistry or similar. Experience in human tissue culture, transfections, microscopy and knowledge in tumor biology/signal transduction would be desired.
If you are interested in working in a highly attractive scientific environment on one of the hot topics in cell and tumor biology you are invited to send us your application.
The full application should contain your CV, description of your technical experience, a letter of motivation, copies of bachelor and master certificates, list of publication and the names and addresses of two referees.
Candidates, who are not yet finished with the Master thesis are also welcome to apply, please include a statement of your university courses/examinations and grades with your application.
Please send your application as a single pdf to: email@example.com
Please send your full application via email as a single pdf file to:
Prof. Dr. Holger Bastians
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Über Georg-August Universität Göttingen
Arbeitsgruppe "Zelluläre Onkologie": Wir sind ein grundlagenwissenschaftliches Labor der Georg-August Universität in Göttingen. Wir sind Teil des Universitätsklinilums (UMG) und des Göttinger Zentrums für Molekulare Biowissenschaften (GZMB). Unser Forschungsfeld beinhaltet die molekulare Analyse des Zellzyklus und der chromosomalen Instabilität in...Mehr über die Georg-August Universität Göttingen