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Postdoc Position in Stem Cell Aging

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The collaborative research group FLI-UKJ of Prof. Dr. Florian Heidel  (UKJ) is
located at the Leibniz-Institute on Aging (FLI) and invites applications for a
 
Postdoc Position in Stem Cell Aging
 
Research focus of the lab / Research projects:
The research group focuses on the functional characterization of genes and signaling pathways that are required for self-renewal and affect aging of hematopoietic stem cells. A key characteristic of hematopoietic stem cells (HSC) is the ability to self-renew. Several genes and signaling pathways control the fine balance between self-renewal and differentiation in HSC and potentially also in leukemic stem cells (LSC). Cell fate determinants, such as RNA-binding proteins or polarity regulators have been recently described as effectors in stem cell biology. Loss of cell polarity influences epithelial cancers and supports tumorigenesis by altering cell-cell-matrix interactions. Additionally, regulation of cell polarity is essential for asymmetric cell division (ACD), and this may influence hematopoiesis and leukemia development.
Recently, we were able to provide evidence that loss of a polarity regulator (Llgl1) enhances fitness and self-renewal potential of hematopoietic stem cells in vivo, and is associated with decreased survival in AML (Heidel et al. J Exp Med 2013).
In the proposed project we aim to dissect the structure of polarity complex members and their interaction in hematopoiesis by gene-expression profiling and mass spectrometry. Moreover, we aim to investigate their functional role in maintenance, adhesion and polarization of adult hematopoietic stem cells using a conditional knockout mouse model.
 
 
Profile of the Candidate / Requirements:
We are looking for enthusiastic and highly motivated applicants holding, or about to obtain, a PhD degree. The applicants should possess a strong research background in molecular and cell biology, previous experience in cancer research will be an advantage. Preference will be given to applicants with previous experience in one or more of the following areas:
  • Molecular biology (experience in cloning)
  • Analysis of cell signaling (protein biochemistry or flow-cytometry based) and
  • In vivo analysis of hematopoiesis or leukemia (using mouse models in hematology, oncology or immunology, as animal work will be mandatory).
 
 
We offer:
  • Integration in a friendly team of highly motivated scientists and physicians working in a well equipped laboratory
  • A position integrated within a collaborative group that connects translational (clinical) aspects (at the University Hospital Campus; UKJ) with basic science (at the FLI and Beutenberg Campus)
  • A contract with the University Hospital (UKJ) according to the collective labor agreement for public service employees of the federal states of Germany (TV-L E13)
  • The position is funded by the DFG (project grant) and will initially be limited to 14 months. Thereafter long-term extension of the contract will be considered.
 
 
Candidates are encouraged to send their application (English) referring to the Job-ID 1625 including CV, list of publication, a short description of research experience and interests and the contact details of two references as soon as possible, not later than October 30th, 2016 to florian.heidel@leibniz-fli.de.
 

Kontaktdaten


Art des Bewerbungszugangs
Candidates are encouraged to send their application (English) referring to the Job-ID 1625 including CV, list of publication, a short description of research experience and interests and the contact details of two references as soon as possible, not later than October 30th, 2016 to florian.heidel@leibniz-fli.de.
 
Kontakt für Bewerbungen
Candidates are encouraged to send their application (English) referring to the Job-ID 1625 including CV, list of publication, a short description of research experience and interests and the contact details of two references as soon as possible, not later than October 30th, 2016 to florian.heidel@leibniz-fli.de.
 

Details der Stellenanzeige


Arbeitszeit
Vollzeit
Vertragslaufzeit
Befristete Anstellung
Stellentyp
Postdoc
Berufserfahrung
Berufserfahrung vorausgesetzt
Region
Deutschland (Thüringen)
Arbeitsort
07745 Jena
Fachgebiet
Biologie & Life Sciences, Humanmedizin
JETZT BEWERBEN