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PhD position in Molecular Biology - DNA demethylation, reprogramming & differentiation

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In the field of “DNA demethylation and development” the research group of Prof. Christof Niehrs offers the following PhD project:
Developmental epigenetics in Xenopus embryos
Description:
In this project we will carry out a screen for novel epigenetic and demethylation regulators in Xenopus (frog) embryos, where microinjection yields facile access to functional analysis of gene function.
We will misexpress candidate epigenetic regulators by mRNA overexpression and antisense Morpholino injection to score for interesting developmental phenotypes. Candidate genes will then be studied by next generation sequencing, including genome-wide gene expression (RNA-seq) to monitor marker gene expression changes and DNA methylation (bisulfite-seq) analysis.  Further characterization of changes in embryonic gene expression will be followed up by genome wide ChIP-seq and bioinformatics analysis.  We will employ a systems biology approach for the understanding of the candidates gene function.  
We offer
•          The possibility to work on a cutting-edge project using state-of-the-art technology in a highly motivated research team
•          A stimulating, diverse and international research environment
•          Advanced training opportunities
•          A competitive stipend
 
Required qualifications
•           Master or Diploma
•           Motivation to solve complex biological problems
•           Excellent communication skills
 
Starting date: 1 September 2016 or later
Duration of stipend: 3 years, with the possibility of extension
Deadline for applications (exclusively online via web form):  1 May 2016

Kontaktdaten


Art des Bewerbungszugangs
Please apply exclusively via our online form at:
https://www.imb-mainz.de/students-postdocs/international-phd-programme/apply-to-ipp/
Kontakt für Bewerbungen
For further questions and contact information please check our website:
http://www.imb.de/PhD

Details der Stellenanzeige


Arbeitszeit
Vollzeit
Vertragslaufzeit
Befristete Anstellung
Stellentyp
Promotionsstelle
Berufserfahrung
Berufserfahrung nicht vorausgesetzt
Region
Deutschland (Rheinland-Pfalz)
Arbeitsort
55128 Mainz
Fachgebiet
Biologie & Life Sciences