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PhD position in Molecular Biology - Proteomic investigation of ubiquitin

In the field of “Deciphering DNA damage signaling using proteomics” the research group of Dr Petra Beli offers the following PhD project:
Understanding ubiquitin signaling in the cellular response to DNA damage
Description:
Posttranslational modification of proteins by ubiquitin is an essential mechanism regulating many cellular processes; in particular protein degradation and DNA repair. Ubiquitin ligases catalyze the attachment of the ubiquitin molecules to lysine residues in target proteins and thereby provide the specificity to the ubiquitin system. Mutations in a number of ubiquitin ligases are associated with neurodegenerative diseases or predisposition to the development of malignancies. However, the protein targets and functions of most ubiquitin ligases in human cells remain elusive. We have recently developed mass spectrometric methods to investigate cellular ubiquitylation patterns and employed these methods to study the response of the ubiquitin system to cellular perturbations including proteasome inhibition and genotoxic stress. The aim of this project is to identify protein substrates and functions of selected ubiquitin ligases implicated in DNA damage repair and signaling. To this end, the PhD candidate will employ a range of methods including mass spectrometry-based proteomics, cell biological and biochemical methods (flow cytometry, confocal microscopy, immunoprecipitation) and functional genomics.
We offer
•          The possibility to work on a cutting-edge project using state-of-the-art technology in a highly motivated research team
•          A stimulating, diverse and international research environment
•          Advanced training opportunities
•          A competitive stipend
 
Required qualifications
•           Master or Diploma
•           Motivation to solve complex biological problems
•           Excellent communication skills
 
Starting date: 1 September 2016 or later
Duration of stipend: 3 years, with the possibility of extension
Deadline for applications (exclusively online via web form):  1 May 2016

How to apply:
Please apply exclusively via our online form at:
https://www.imb-mainz.de/students-postdocs/international-phd-programme/apply-to-ipp/
Kontakt für Bewerbungen
For further questions and contact information please check our website:
http://www.imb.de/PhD
Bitte beziehen Sie sich bei Ihrer Bewerbung auf jobvector und geben Sie die folgende Referenznummer an: JV-C10-PB1

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Über Institute of Molecular Biology gGmbH

Our International PhD Programme on the “Gene Regulation, Epigenetics and DNA Damage Response” gives talented and enthusiastic students the opportunity to undertake PhD research at the cutting edge of modern biology. Our groups cover a broad range of expertise and include leading biochemists, geneticists, cell and developmental biologists who study the molecular mechanisms of...

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