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PhD position in Molecular Biology – Telomere biology

In the field of “Telomere biology” the research group of Dr Brian Luke offers the following PhD project:
 
 
Understanding the crosstalk between checkpoint and nutrients
 
Description:
 
With regards to the non-coding RNA TERRA, we are using yeast and human cells to understand how RNA-DNA hybrids (R-loops) are regulated at telomeres throughout the cell cycle and also in cells that have escaped senescence (similar to cancer cells using the ALT mechanism). We are employing live cell microscopy, chromatin immunoprecipitation, Southern blotting and many other molecular, genetic and biochemical assays to address these questions. We believe that a better understanding of TERRA regulation could eventually provide a specific means to target ALT cancers.
 
For the checkpoint adaptation projects, we are now focusing on chemotherapeutic drugs and addressing how the manipulation of the checkpoint can influence the efficacy of such drugs. Here also we are employing both yeast and human cells to interrogate these questions. We want to understand how the molecular signaling between metabolic pathways and the checkpoint is organized. Our preliminary data suggests that this interaction has an important influence on whether or not cells become resistant to chemotherapeutics.
 
 
We offer
• The possibility to work on a cutting-edge project using state-of-the-art technology in a highly motivated research team
• A stimulating, diverse and international research environment
• Advanced training opportunities
• A competitive stipend
 
Required qualifications
• Master or Diploma
• Motivation to solve complex biological problems
• Excellent communication skills

 
Starting date: 1 September 2016 or later
Duration of stipend: 3 years, with the possibility of extension
Deadline for registration (exclusively online via web form):  8 May 2016

How to apply:
Please apply exclusively via our online form at:
https://www.imb-mainz.de/students-postdocs/international-phd-programme/apply-to-ipp/
Kontakt für Bewerbungen
For further questions and contact information please check our website:
http://www.imb.de/PhD
Bitte beziehen Sie sich bei Ihrer Bewerbung auf jobvector und geben Sie die folgende Referenznummer an: JV-C10-BL1

Über Institute of Molecular Biology gGmbH

Our International PhD Programme on the “Gene Regulation, Epigenetics and DNA Damage Response” gives talented and enthusiastic students the opportunity to undertake PhD research at the cutting edge of modern biology. Our groups cover a broad range of expertise and include leading biochemists, geneticists, cell and developmental biologists who study the molecular mechanisms of...

Mehr über die Institute of Molecular Biology gGmbH

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