Alvotech is a global biopharmaceutical company dedicated to become one of the leaders in the biosimilar monoclonal antibody market. Alvotech is an independent sister company of the international pharmaceuticals company Alvogen. The company is headquartered in Reykjavik, Iceland, and has an increasingly global presence and a broad network of partners around the world.
Alvotech has six key biosimilar molecules in development and a new state-of-the-art manufacturing plant for development and commercial supply. Alvotech is investing over $500 million in the development of its pipeline and facility.
Within Alvotech Germany we are currently recruitung an experienced
Head Downstream Development (m/f)
At the site in Jülich, Germany, Alvotech focuses on process development for its biosimilar pipeline, including cell line development, upstream and downstream processing as well as analytics. The head DSP will be responsible for the buildup of a DSP unit and the successful integration of its activities into the workflow of adjacent departments like upstream development and analytics. He or she will be in charge of managing projects to develop, characterize and validate processes for the purification of monoclonal antibodies from mammalian cell culture.
Most important tasks of the job:
Lead process development, characterization and validation projects (purification, UF/DF, virus removal, formulation)
Ensure successful scale-up and transfer of developed processes
Develop appropriate scale-down models in cooperation with the DSP team of the manufacturing site in Iceland
Initialize and maintain collaborations with third party reseach organizations
Actively communicate with and support other departments
Supervision and training of PhDs, engineers and lab technicians
Compilation of QA compliant development reports, SOPs and technology transfer documents
Accountable for the recruiting of adequate personnel
Aquisition of necessary lab equipment
The head DSP reports to the Chief Scientific Officer.
PhD in biochemistry, biotechnology, biology or related with 7+ years of BioPharma, BioPharmaceutical, Pharmaceutical or Biotechnology industry experience
Excellent management and leadership experience
Strong scientific and engineering expertise managing downstream protein purification processes for the generation of monoclonal antibody and recombinant protein therapeutic products
Hands-on expertise engineering and operating downstream processing equipment including filtration, chromatography skids, and TFF
Expertise leading scale-up, technology transfer and process validation (PQ) activities
Working experience in the application of DoE and QbD principles
Broad scientific knowledge and critical thinking
Excellent communication skills, good presentation and writing skills
Very good command of English, German highly beneficial
What we offer:
In response to our innovative and stimulating atmosphere of a multicultural and demanding environment, we offer opportunities to bring forward ideas, lead change as well opportunities for personal development and growth in an international company.
Should you be interested, please send your complete curriculum vitae in English, references (including certificates, both in one pdf - document), salary expectations, and your earliest possible starting date by applying online to Mrs. Iris Landen: firstname.lastname@example.org