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The Microenvironmental and Metabolic Control Of Tumor Progression and Metastasis

The Institute of Neuropathology at the Justus Liebig University in Giessen, Germany, Director Prof. Till Acker, is inviting applications for a
Postdoc position:
The microenvironmental and metabolic control of tumor progression and metastasis

The position is available immediately.
Your profile
We are looking for enthusiastic and highly motivated applicants holding, or about to obtain, a PhD degree. The applicants should possess a strong research background in molecular and cell biology, experience in cancer research will be an advantage. Preference will be given to applicants with previous experience in one or more of the following areas: protein biochemistry, proteomic analysis including analysis of posttranslational modifications, hypoxic signalling, metabolic analysis and metabolic signalling, receptor tyrosine kinase (RTK) signalling, functional genomics or other high-throughput screening methods, in vivo tumor metastasis models.
Our group has a long-standing interest in the role of microenvironmental factors, particularly hypoxia, hypoxia inducible factors (HIFs) and oxygen sensors of the PHD family, in the regulation of tumor progression and key hallmarks of cancer including angiogenesis, invasion, metastasis, metabolism and differentiation. Our main research interest is to understand the role of microenvironmental sensors and their downstream targets in tumor progression and metastasis.
The proposed projects will aim to dissect the intersection of oxygen sensing pathways with other cellular signalling pathways, including growth factor/RTK and metabolic signalling, which are involved in cancer cell proliferation, invasion, metastasis and self-renewal.
What we offer
Our international team offers an open, supportive, dynamic and motivating academic environment with excellent training opportunities. We have won a number of external research grants and are involved in several national and international collaborative projects. We use a wide spectrum of methods: cloning, cell culture, biochemistry, qRT-PCR, FACS, ELISA, cell-based assays (proliferation, apoptosis, migration, 3D invasion, stem cell isolation and cultivation etc.), shRNA/siRNA screens, proteomics, transactivation assays, virally-based gene delivery and RNAi or CRISPR/Cas9-mediated silencing, immunohistochemistry, in situ hybridization, light, epifluorescence and confocal microscopy, image analysis, animal models and in vivo tumor models.

Please send your applications, including a CV, certificates and references to Dr. Boyan Garvalov
Email: Boyan.Garvalov at patho.med.uni-giessen.de;
Please cite reference ID “Naturejobs Postdoc 2015-02”.
Selected references
Henze et al, Nature Commun 2014, 5:5582
Garvalov et al, Nature Commun 2014, 5:5577
Filatova et al, Biochim Biophys Acta 2013, 1830(2):2496-508
Sawamiphak et al, Nature 2010; 465(7297):487-91
Henze et al, Cancer Research 2010;70(1):357-66
Seidel et al, Brain 2010;133(4):983-95
Acker et al, Cancer Cell 2005; 8(2):131-41
Compernolle et al, Nature Medicine 2002; 8(7):702-10
How to apply:
Please send your applications, including a CV, certificates and references to Dr. Boyan Garvalov
Email: Boyan.Garvalov at patho.med.uni-giessen.de;
Please cite reference ID “Jobvector Postdoc 2015-02”.
Kontakt für Bewerbungen
Email: Boyan.Garvalov at patho.med.uni-giessen.de;
Bitte beziehen Sie sich bei Ihrer Bewerbung auf jobvector und geben Sie die folgende Referenznummer an: Jobvector Postdoc 2015-02

Über Justus-Liebig-Universität

Unser wissenschaftlicher Schwerpunkt liegt in der Erforschung der Bedeutung des Tumormikromilieus in Tumorprogression, -invasion und -metastasierung sowie der molekularen Mechanismen neuromuskulärer Erkrankungen.

Mehr über die Justus-Liebig-Universität

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