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A Ph. D position in Molecular Cell Biology & Genetics

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A Ph. D position in Molecular Cell Biology & Genetics at the TUM (Technische Universität München), Germany
is available as of February 2015 in the group of Dr. habil. Farhah Assaad (www.botanik.wzw.tum.de/index.php?id=15).
 
 
Topic: The trans-Golgi network (TGN) is a major hub for the flow and sorting of information from and to the cell surface. The molecular mechanisms underlying protein sorting at the TGN, however, are poorly understood. The focus of our research is on the regulation of protein sorting at the TGN in the context of cytokinesis, the partitioning of the cytoplasm following nuclear division. The Arabidopsis TRAPPII tethering complex, thought to function as a guanidine exchange factor (GEF) regulating Rab GTPase activity, is emerging as a central player in cytokinesis and in post-Golgi traffic1,2. We have identified interaction partners of the TRAPPII complex via proteomic approaches and are testing the role of a subset of these in protein sorting at the cell plate. We will also address rewiring of the TRAPPII proteome in response to environmental stimuli. Our experimental plan integrates molecular genetics, physiology, biochemistry, proteomics, computational and cell biological methods, including super-resolution confocal live imaging microscopy and focused ion beam/scanning electron microscopy, to address TGN structure and function. The outcome of the proposed experiments will considerably further our understanding of protein sorting at specialized TGN compartments such as the cell plate, and of the role of the TGN in driving and fine tuning plant growth and adaptation.
 
Methodologies: My laboratory works with the model plant Arabidopsis thaliana and deploys a broad range of methods, including mutant analysis, molecular biology, confocal microscopy (CSLM), genetics and biochemistry. We have collaborations with other groups for Mass Spectrometry, network analysis, high-resolution confocal microscopy and electron microscopy. A Ph. D student will benefit from the vast expertise of this research consortium and will be enrolled at the TUM graduate school.
 
Application: Applicants are expected to have a degree in the life sciences (biology, biochemistry, biophysics, biotechnology…). Please mail a cv (including contact information for two references), transcript of records and motivation letter as a single PDF in either German or English to farhah@wzw.tum.de.
 
Application deadline: February 20th, 2015.
 
The  salary is in accordance with “Tarifvertrag für den Öffentlichen Dienst der Länder”
TV-L E13/2. The TUM is an equal opportunity employer and qualified women are particularly encouraged to apply.
 
 
 
  • Rybak K, Steiner A, Synek L, Klaeger S, Kulich I, Facher E, Wanner G, Kuster B, Zarsky V, Persson S, Assaad FF (2014) Dev Cell 29:607-20.

  • Thellmann M, Rybak K, Thiele K, Wanner G, Assaad FF (2010) Plant Physiol.154:720-32.

Kontaktdaten


Art des Bewerbungszugangs
E-Mail: farhah@wzw.tum.de

Application deadline: February 20th, 2015.


 
Kontakt für Bewerbungen
Ihre Bewerbung richten Sie bitte an:
Frau PD Dr. Farhah Assaad
Lehrstuhl für Botanik-TUM
Emil-Ramann-Straße 4
85354 Freising
E-Mail: farhah@wzw.tum.de

 

Details der Stellenanzeige


Arbeitszeit
Teilzeit
Vertragslaufzeit
Befristete Anstellung
Stellentyp
Promotionsstelle
Berufserfahrung
Berufserfahrung nicht vorausgesetzt
Region
Deutschland (Bayern)
Arbeitsort
85354 Freising - Weihenstephan, Deutschland
Fachgebiet
Biologie & Life Sciences
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