PhD fellowship in biology and life sciences

 Klinikum der Universität Erlangen  Erlangen
Work environment: We are an international laboratory for translational matrix biology with appr. 25 researchers. We are closely linked to other research facilities in Erlangen (Dep. of Rheumatology and Immunology, Dep. of Animal Physiology, and Interdisciplinary Center for Clinical Research). We have national and international cooperation partners in academics and industry. Our major gaols are to identify novel anti-fibrotic targets, elucidate the underlying pathogenic pathways and come up with candidate therapies for clinical use. We are focusing autoimmune diseases associated with skin and lung fibrosis.
Topic: The student’s project will focus on the role of so-called innate lymphoid cells (ILCs) in the pathogenesis of rheumatic diseases and in their role during fibrogenesis. ILCs are a relatively novel innate immune counterpart of adaptive T-helper cells. ILCs can be further subdivided into ILC1, ILC2 and ILC3 cells that mirror the functions of T cell subpopulations. Deregulation of ILC numbers or functions have been implicated in various diseases including fibrotic diseases. In the proposed topic, we are aiming to further characterize the role of ILCs in rheumatic diseases and to investigate potential therapeutic implications.
Methods: We offer a broad spectrum of molecular techniques to analyze matrix metabolism. The student will work with FACS, immunohistochemistry, immunofluorescence, qPCR, ELISA, WB, nucleofection, siRNA, reporter assay, ChIP assay among other methods. The student’s project will comprise various in vitro (cell culture) and in vivo systems (genetic and non-genetic mouse models). The protocols for detection of ILC2s in blood and tissues are already established.
Requirements and application: We invite applications by students holding a master's or comparable degree in biological or biomedical sciences (biology, molecular biology, immunology, biochemistry). We appreciate applications from highly motivated students with basic knowledge in the above-mentioned techniques. Previous work with in vivo models is desirable but not necessary. Organizational and communication skills as well as the ability to work independently but also in a team are very welcomed. Good English and or German skills are essential to work within our laboratory. Funding for a 3-year employment is available.

How to apply:
Please send electronic applications to the hands of Prof. Dr. Jörg Distler before July 15th, 2015, including cover letter, recent CV, copies of your certificates as well as two names of reference with contact details. Please don’t hesitate to ask further questions.
Tel.: 0049 (0)9131 43008
Kontakt für Bewerbungen
Prof. Dr. Jörg Distler
Heisenberg Professor for Fibrosis Research
Department of Internal Medicine 3
University of Erlangen-Nuremberg
Ulmenweg 18
91054 Erlangen
Tel.: 0049 (0)9131 43008
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