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PhD position in Molecular Biology - Decoding DNA damage signaling

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In the field of "Decoding DNA damage signaling using quantitative mass spectrometry" the research group of Dr. Petra Beli offers the following PhD project:

Identification of protein targets of ubiquitin ligases implicated in DNA repair and chromatin remodeling.

Description:
Protein ubiquitylation is involved in diverse cellular processes including protein degradation, DNA damage repair and chromatin remodeling. We have recently developed mass spectrometric methods to investigate cellular ubiquitylation patterns and employed these methods to study the response of the ubiquitin system to cellular perturbations including the proteasome inhibition and genotoxic stress (Wagner and Beli et al. 2011 and 2012; Povlsen and Beli et al. 2012). We have shown that DNA damage induces site-specific ubiquitylation and deubiquitylation of DNA repair factors highlighting the regulatory role of protein ubiquitylation in DNA repair. Ubiquitin ligases play an essential role in ubiquitin system by defining its substrate specificity. However, the protein targets and functions of most ubiquitin ligases remain elusive. The aim of the project is to identify and to characterize the substrates of selected ubiquitin ligases implicated in DNA repair and chromatin organization. To this end, the prospective PhD student will employ mass spectrometric methods for analysis of protein ubiquitylation as well as advanced cell biological and biochemical methods including flow cytometry, confocal microscopy and immunoprecipitation.


We offer
  • The possibility to work on a cutting-edge project using state-of-the-art technology in a highly motivated research team
  • A stimulating, diverse and international research environment
  • Advanced training opportunities
  • A competitive stipend

Required qualifications
  • Master or Diploma
  • Motivation to solve complex biological problems
  • Excellent communication skills


Starting date: 1 March 2015 or later
Duration of stipend: 3 years, with the possibility of extension
Deadline for applications (exclusively online via web form):  08 November 2014


 

Kontaktdaten


Art des Bewerbungszugangs
Please apply exclusively via our online form at:

http://www.imb.de/students/international-phd-programme/applyipp/
 
Kontakt für Bewerbungen
For further questions and contact information please check our website:

http://www.imb.de/PhD



 

Details der Stellenanzeige


Arbeitszeit
Vollzeit
Vertragslaufzeit
Befristete Anstellung
Stellentyp
Promotionsstelle
Berufserfahrung
Berufserfahrung nicht vorausgesetzt
Region
Deutschland (Rheinland-Pfalz)
Arbeitsort
55128 Mainz
Fachgebiet
Biologie & Life Sciences