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PhD position in Molecular Biology - Epigenetic gene regulation acute myeloid leukaemia

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In the field of  “Epigenetic gene regulation acute myeloid leukaemia” the research group of Prof. Thomas Kindler offers one PhD project.

Description:
In this project we aim to understand the specific role of mutant FLT3 (FLT3-ITD) on epigenetic gene regulation. We will make use of several well characterized human AML cell lines and generate syngeneic cells expressing either wild-type FLT3 or FLT3-ITD. The PhD student will perform global gene expression profiling by RNA-sequencing, histone modifications will be investigated by ChIP-Seq analyses. Further, FLT3-ITD expressing cells will be treated with specific FLT3-inhibitors and their effects on global chromatin modification will be analysed. FLT3-ITD-dependent histone modifications and involved epigenetic regulators will be further characterized by immunoblot analysis, ChIP and shRNA-mediated gene knockdown allowing us to identify FLT3-ITD-specific epigenetic targets. Finally, promising therapeutic strategies will evaluated at the leukemic stem cell level using a well-established murine Flt3+/ITD:Dnmt3afl/fl:Mx1-Cre+ leukemia model. 

We offer
•    The possibility to work on a cutting-edge project using state-of-the-art technology in a highly motivated research team
•    A stimulating, diverse and international research environment
•    Advanced training opportunities
•    A competitive stipend

Required qualifications
•    Master or Diploma
•    Motivation to solve complex biological problems
•    Excellent communication skills

Starting date: October 2015 or later
Duration of stipend: 3 years, with the possibility of extension
Deadline for registration (exclusively online via web form):  20 June 2015
 

Kontaktdaten


Art des Bewerbungszugangs
https://www.imb-mainz.de/students-postdocs/international-phd-programme/apply-to-ipp/
Kontakt für Bewerbungen
http://www.imb.de/PhD

Details der Stellenanzeige


Arbeitszeit
Vollzeit
Vertragslaufzeit
Befristete Anstellung
Stellentyp
Promotionsstelle
Berufserfahrung
Berufserfahrung nicht vorausgesetzt
Region
Deutschland (Rheinland-Pfalz)
Arbeitsort
55128 Mainz
Fachgebiet
Biologie & Life Sciences, Pharma