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PhD position in Molecular Biology - Genomic views of protein-RNA interactions & splicing regulation

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In the field of  “Genomic views of protein-RNA interactions & splicing regulation” the research group of Dr. Julian König offers the following PhD project:

Illuminating a key player in splicing regulation

The human RNA-binding protein PTB is a central regulator of alternative splicing with strong impact on neuronal differentiation. It recognizes a multitude of target exons to affect their splicing in distinct ways, leading to the coordinated expression of tissue-defining transcript isoforms. However, it is unclear how this versatile protein differentiates between activities and achieves specificity in activating or repressing certain exons.
The aim of this project is to dissect the PTB splicing regulatory network and its molecular mechanisms using next-generation sequencing-based technologies that are currently revolutionizing RNA biology. Among these, the PhD student will map protein-RNA interactions on a genome-wide scale using iCLIP and identify the responsible cis-regulatory splicing signals through a systematic mutational screen that we recently developed in the lab. These approaches will be complemented by the identification of protein partners using quantitative mass spectrometry. Insights from the genome-wide approaches will be followed up with genetic and biochemical experiments to nail down mechanistic principles of regulation.

We offer
•    The possibility to work on a cutting-edge project using state-of-the-art technology in a highly motivated research team
•    A stimulating, diverse and international research environment
•    Advanced training opportunities
•    A competitive stipend

Required qualifications
•    Master or Diploma
•    Motivation to solve complex biological problems
•    Excellent communication skills

Starting date: October 2015 or later
Duration of stipend: 3 years, with the possibility of extension
Deadline for registration (exclusively online via web form):  20 June 2015


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Details der Stellenanzeige

Befristete Anstellung
Berufserfahrung nicht vorausgesetzt
Deutschland (Rheinland-Pfalz)
55128 Mainz
Biologie & Life Sciences