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PhD position in Molecular Biology - Role of Sirt6 during cellular differentiation and cancer

Diese Stellenanzeige ist abgelaufen. Finden Sie hier zahlreiche ähnliche Jobs.

In the field of  “Role of Sirt6 during cellular differentiation and cancer” the research group of Prof. Susanne Strand offers the following PhD project:

Role of Sirt6 during hepatocellular differentiation and tumor development

Description:

The chromatin-associated histone deacetylase Sirt6 is involved in epigenetic gene silencing. In our previous work we found a deregulation of central differentiation factors in Sirt6-deficient hepatocytes. Based on the importance of cell fate decisions in stem cell differentiation and cancer development we will analyze the role of Sirt6 in vitro and in vivo by using our well-established differentiation and tumor models. The methods that will be used to work on this project are cell culture of tumor cells, Immunoprecipitation, Western Blot, RT-PCR, RNA-Seq, RIP, ChIP, Reporter Gen Assay, Chromosome Conformation Capture, Immunofluorescence, FACS- Analysis and Confocal Laser Scanning Microscopy.

We offer
•    The possibility to work on a cutting-edge project using state-of-the-art technology in a highly motivated research team
•    A stimulating, diverse and international research environment
•    Advanced training opportunities
•    A competitive stipend

Required qualifications
•    Master or Diploma
•    Motivation to solve complex biological problems
•    Excellent communication skills

Starting date: 1 March 2015 or later
Duration of stipend: 3 years, with the possibility of extension
Deadline for registration (exclusively online via web form):  8 November 2014

Kontaktdaten


Art des Bewerbungszugangs
Please apply exclusively via our online form at:
http://www.imb.de/students/international-phd-programme/applyipp/
 
Kontakt für Bewerbungen
For further questions and contact information please check our website:
http://www.imb.de/PhD

Details der Stellenanzeige


Arbeitszeit
Vollzeit
Vertragslaufzeit
Befristete Anstellung
Stellentyp
Promotionsstelle
Berufserfahrung
Berufserfahrung nicht vorausgesetzt
Region
Deutschland (Rheinland-Pfalz)
Arbeitsort
55128 Mainz
Fachgebiet
Biologie & Life Sciences, Humanmedizin