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PhD Student (Biochemistry)

 Radboud University Medical Center  6500HB Nijmegen
For the project “Redox Control of the Active/Deactive Regulation of Mitochondrial Complex I” within the Priority Program „Dynamics of Thiol-based Redox Switches in Cellular Physiology” (SPP 1710: www.thiolswitches.de) of the German Research Foundation (DFG), the Nijmegen Center for Mitochondrial Disorders (www.ncmd.nl), The Netherlands is looking for a
 
PhD Student (Biochemistry)
 
The Project aims at understanding the molecular mechanism of the active/deactive transition of mitochondrial complex I and how it is controlled by modification of the cysteine in subunit ND3. We will use our recently solved X-ray crystallographic structure of mitochondrial complex I that suggests significant structural changes between the A- and D-from of complex I around its cysteine switch, to build structural models of the two states based on Molecular Dynamics simulations. This information will be used to guide a mutagenesis study aimed at identifying the protein domains and residues critically involved in the A/D transition in order to understand the structural changes associated with this process at the atomic level. In a second part of the project we will study how the A/D transition and the associated cysteine switch is controlled depending on the functional state of mitochondria. For this we will develop a quantitative redox-proteomic strategy to address the A/D transition state and the status of the associated cysteine switch in mitochondria and cells.
 
We expect a grade in Biochemistry, Biology, Chemistry or Molecular Medicine. Experience in the field of Biochemistry and Proteomics, especially of membrane protein ­complexes is a plus. The successful candidate will be fluent in English and show enthusiasm, a proactive attitude, and will enjoy working in a team.
 
We offer a highly attractive research environment in a strong and internationally renowned team.
 
Please send your email application including a letter of intent, a curriculum vitae, certificates, letters of recommendation and references to Prof. Dr. Ulrich Brandt (ulrich.brandt@radboudumc.nl) Application deadline: August 15, 2015
 
How to apply:
Please apply by Email with a letter of intent, your CV and copies of relevant certificates.
Kontakt für Bewerbungen
Prof. Dr. Ulrich Brandt
Email: ulrich.brandt@radboudumc.nl
http://www.ncmd.nl/3242/Structure-and-function.html
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