PhD student (Doktorand, m/w) in Immunology & Hemostaseology

The Center for Thrombosis and Hemostasis, Department of Hematology, Pneumology and Oncology of the University Medical Center Mainz, laboratory of Dr. Markus Bosmann is seeking a highly qualified:
PhD candidate student in Immunology & Hemostaseology (m/f)
The University Medical Center Mainz of the Johannes Gutenberg University Mainz is ranked as a leading research institution of Germany having a strong immunology program. Our laboratory is affiliated to the Center for Thrombosis and Hemostasis (CTH), funded by the German Ministry of Education and Research (BMBF) as well as the Department of Hematology, Pneumology and Oncology. Objectives of the PhD program are to create an attractive environment for basic & translational research and improved career opportunities for young researchers.
We are looking for a highly motivated PhD candidate student to study the mechanisms of innate and adaptive immunity during sepsis (bacterial infection) and acute lung injury. The projects aim to investigate the molecular interactions of immune responses and the coagulation system. A special area of interest is the role of complement receptors (C5aR1, C5aR2), cytokines and related signaling pathways as well as role of novel pathogen associated molecular patterns.
These basic and translational research projects are primarily conducted in surgical mouse models of experimental sepsis (cecal ligation & puncture) / acute lung injury, and require state-of-the-art techniques in immunology, molecular biology and hemostaseology. Complex mouse breeding strategies (cre-lox system) and generation of bone-marrow chimeric mice will be performed. In addition, cell culture techniques (isolation of macrophages, neutrophils, platelets) as well as flow cytometry, RT-PCR, ChIP assays, ELISA, Western blotting, bead-based assays, aggregometry, lentiviral transductions, immunostainings, intra-vital microscopy, CRISPR-Cas9 genome editing and massive parallel sequencing technologies will be employed.
The PhD student will have opportunities in designing as well as conducting independent projects. The duration of the projects will be 3-4 years. Based on individual credentials and experience, an application for extramural PhD stipends is encouraged.
An M.Sc. or diploma degree in a relevant field is required and a strong background in Immunology, Molecular Biology and/or Hemostaseology is preferred. Ability in initiating, conducting, evaluating and reporting of research studies is essential. Experiences with tissue cultures, transgenic mouse models and molecular biology methodologies are desirable. Excellent verbal and written communication skills are required.
The PhD student will have the opportunity to work with an interdisciplinary and highly motivated team of scientists and clinicians. Further information is available:
How to apply:
Please send your application materials (CV, letter of motivation, list of references, official transcripts: diplomas, Abiturzeugnis) in English or German to Dr. Markus Bosmann:


Kontakt für Bewerbungen
Dr. Markus Bosmann
Centrum für Thrombose und Hämostase (CTH)
III. Medizinische Klinik für Hämatologie, Onkologie und Pneumologie
Universitätsmedizin Mainz
Langenbeckstr. 1
55131 Mainz
Tel: 06131-17-8277

Details der Stellenanzeige

Befristete Anstellung
Berufserfahrung nicht vorausgesetzt
Deutschland (Rheinland-Pfalz)
55131 Mainz
Biologie & Life Sciences, Agrarwissenschaften, Chemie, Geowissenschaften, Informatik, Mathematik, Pharma, Physik

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