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PhD student: Studying the role of proline peptidases in cell migration and cell survival

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An open position for a Ph.D. / doctoral student is available in the Center for Biochemistry and Molecular Cell Biology in Goettingen, Germany. The aim of project is to study the functional roles and regulations of peptidases, using biochemical and cell biology methods. The position will be financed for three years by the Deutsche Forschungsgemeinschaft (DFG), and is available from November 2014 (can be started later).  
The successful candidate will join a young and still growing independent group in a stimulating and dynamic working environment with highly interacting groups and excellent research facilities. A major interest in the lab is studying the biochemistry and cellular biology of Dipeptidyl peptidases (DPP). Members of this family have important roles in regulating the activity of peptide hormones, neuropeptides and the immune system. The aim of the proposed PhD project is to characterize novel substrates of DPP9, a rate-limiting enzyme for cleavage of proline-containing peptides in the cytosol that is essential for neonatal survival.

We are looking for a motivated, hard working and talented Ph.D. applicant who is curious and open for new challenges. A good understanding and interest in biochemistry and experience in cell culture and molecular biology is an advantage. The University of Goettingen is an equal opportunities employer and places particular emphasis on fostering career opportunities for female scientists. Applications should include your curriculum vitae, name of contact persons for letters of reference, copies of university certificates and a cover letter summarizing relevant work experience and motivation. Please send your application to Ruth Geiss-Friedlander More information on our lab can be found in: Center for Biochemistry and Molecular Cell Biology, Humboldtallee 23, 37073 Göttingen, Germany.

Justa-Schuch, D., Möller, U. & Geiss-Friedlander, R. The amino terminus extension in the long dipeptidyl peptidase 9 isoform contains a nuclear localization signal targeting the active peptidase to the nucleus. Cell. Mol. Life Sci. 71, 3611–3626 (2014).
Pilla, E., Kilisch, M., Lenz, C., Urlaub, H. & Geiss-Friedlander, R. The SUMO1-E67 interacting loop peptide is an allosteric inhibitor of the dipeptidyl peptidases 8 and 9. J. Biol. Chem. 288, 32787–32796 (2013).
Pilla, E.. Möller, U., Sauer, G., Mattiroli, F., Melchior, M. and Ruth Geiss-Friedlander. A novel SUMO1-specific interacting motif in dipeptidyl peptidase 9 (DPP9) that is important for enzymatic regulation. J. Biol. Chem. 287, 44320–44329 (2012).


Art des Bewerbungszugangs
Please apply by e-mail or post.
Kontakt für Bewerbungen
Dr. Ruth Geiss-Friedlander
University Medical Center Göttingen
Center for Biochemistry and Molecular Cell Biology
Humboldtallee 23,
37073 Göttingen

Phone: +49-(0)551-395984
Fax: +49-(0)551-395960

Details der Stellenanzeige

Befristete Anstellung
Berufserfahrung vorausgesetzt
Deutschland (Niedersachsen)
37073 Göttingen
Biologie & Life Sciences