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PhD Fellowship - H2020-MSCA-ETN -675448

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Project background and goal: Endoplasmic reticulum (ER) stress is now emerging as a common feature in the pathology of numerous diseases including cancer, neurodegenerative disorders, metabolic syndromes and inflammatory diseases, annually affecting millions of patients worldwide, and posing an enormous cost burden on the health sector. ER stress is caused by impaired function of the ER and accumulation of unfolded proteins in this compartment which triggers a set of signalling pathways termed the unfolded protein response (UPR). The UPR is an adaptive response that aims to resolve the stress through a multi-pronged approach, however, when ER stress cannot be resolved, the UPR induces cell death. The molecular mechanisms involved in transition of the UPR from a protective to a death response are incompletely understood, but are fundamental to developing strategies to limit or avoid the pathological consequences of ER stress. Therefore understanding the ER stress response has the potential to allow us to tackle many ER stress-associated diseases and it thus represents a potential therapeutic intervention point that can be exploited to develop novel therapies and new diagnostic and prognostic markers for a wide range of diseases.
The TRAIN-ERS programme will bring 14 young researchers together with world-leading academics, clinicians and industry personnel, who will form a network of excellence aimed at understanding the ER stress response and applying this understanding to provide knowledge-driven strategies for the treatment of ER stress-associated diseases. The researcher (ESR6) recruited to the Goethe-University, Frankfurt, Germany, will be a part of this exciting network with the opportunity for excellent scientific training as well acquiring transferable skills and carrying out industrial secondments.
 
Career Stage
Early Stage Researcher (ESR) or 0-4 yrs. (Post Graduate)
 
Benefits and salary
The MSCA programme offers a highly competitive and attractive salary and working conditions. The successful candidates will receive a salary in accordance with the MSCA regulations for early stage researchers. Exact salary will be confirmed upon appointment [Living Allowance = €3110/month (correction factor to be applied per country) + mobility allowance = €600/month. Researcher’s may also qualify for a family allowance of €500/month depending on the family situation].
In addition to their individual scientific project, the fellow will benefit from further continuing education, which includes scientific skills courses, transferable skills courses, as well as active participation in workshops and conferences and the opportunity to go on secondments to partner labs.
 
Applicants need to fully comply with the three eligibility criteria:
  • Early-stage researchers(ESR) are those who are, at the time of recruitment by the host, in the first four years (full-time equivalent) of their research careers. This is measured from the date when they obtained the degree which formally entitles them to embark on a doctorate, either in the country in which the degree was obtained or in the country in which the research training is provided, irrespective of whether or not a doctorate was envisaged. Please note applicants cannot already hold a PhD.
  • Conditions of international mobility of researchers: Researchers are required to undertake trans-national mobility (i.e. move from one country to another) when taking up the appointment. At the time of selection by the host organisation, researchers must not have resided or carried out their main activity (work, studies, etc.) in Ireland for more than 12 months in the 3 years immediately prior to their recruitment. Short stays, such as holidays, are not taken into account.
  • English language: Network fellows (ESRs) must demonstrate that their ability to understand and express themselves in both written and spoken English is sufficiently high for them to derive the full benefit from the network training.
  •  
    Application procedure:
    Applications should include a detailed CV including the contact details of three references and a one page motivation letter describing your research career goals, skills and experience. Please send applications by e-mail (in PDF only) to jobs@kinderkrebsstiftung-frankfurt.de by 30 June 2016.
    Successful applicants will need to prove that they are eligible (three aspects: respect ESR definition, mobility criteria, and English language proficiency) and will be required to provide transcripts. 
     
     
    Project
     
    ESR6: UPR as a novel therapeutic target in paediatric cancers
    This project will focus on exploring the potential of targeting the UPR in paediatric cancers. ESR6 will screen a large number paediatric cancer cell lines and primary patient material for sensitivity to ER stress inducers to identify childhood cancers that are particularly prone to ER stress. Combinations of ER stress inducers and other cytotoxic drugs will be tested to identify synergistic drug interactions and a synthetic lethality screening assay using a genome-wide shRNA library will be used to discover novel candidate genes that regulate ER stress-triggered cell death in childhood cancers. Candidate genes will be characterized and validated in cell culture and in vivo using the chorioallantois membrane model.
    Host: Goethe University Hospital Frankfort - GUF (Frankfurt, Germany)

Kontaktdaten


Art des Bewerbungszugangs
Please send applications by e-mail (PDF only) to jobs@kinderkrebsstiftung-frankfurt.de
Kontakt für Bewerbungen
jobs@kinderkrebsstiftung-frankfurt.de

Details der Stellenanzeige


Arbeitszeit
Vollzeit
Vertragslaufzeit
Befristete Anstellung
Stellentyp
Promotionsstelle
Berufserfahrung
Berufserfahrung nicht vorausgesetzt
Region
Deutschland (Hessen)
Arbeitsort
60528 Frankfurt
Fachgebiet
Biologie & Life Sciences
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