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PhD Position in Translational Stem Cell Research

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A PhD position is available at the Institute of Reconstructive Neurobiology (Head: Professor Oliver Brüstle), University of Bonn Medical School, Germany.
The work will be carried out in the Research Group of PD Dr. med. Philipp Koch
The group is interested in the analysis of pathophysiological changes associated with neurodegenerative and neuropsychiatric disorders using culture systems based on induced pluripotent stem cells generated by cellular reprogramming or directly converted neurons from somatic cells. Work will include the cultivation of induced pluripotent stem cells, neural differentiation and assessment of phenotypic changes by molecular and biomedical analysis. Applied methods are: cell culture techniques, Western blot, RT-PCR, immunocytochemical analysis and microscopy.
The Institute for Reconstructive Neurobiology is embedded in the Bonn Neuo-Campus. Here, top notch neuroscience reserach institutes, clinical departments and the German Center for Neurodegenerative Disease (DZNE) are located building a vibrant neuro research community.

Potential applicant could also participate at the Bonn Neuroscience Gradschool program BIGS (
If you are a highly motivated student with strong interest for basic research and state of the art life sciences please apply by email and include a CV, your certificates and a brief ‘letter of motivation’. Applications in German and English language will be considered.
Koch, P., Breuer, P., Peitz, M., Jungverdorben, J., Kesavan, J., Poppe, D., Doerr, J., Ladewig, J., Mertens, J., Tüting, T., Hoffmann, P., Klockgether, T., Evert, B.O., Wüllner, U., Brüstle, O. “Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease.” Nature. Nov 23;480(7378):543-6. (2011
Mertens, J., Stüber, K., Wunderlich, P., Ladewig, J., Vandenberghe, R., Vandenbulcke, M., van Damme, P., Walter, J., Brüstle, O., and Koch, P., “APP Processing in Human Pluripotent Stem Cell-Derived Neurons is Resistant to NSAID-based γ-Secretase Modulation” Stem Cell Reports 1(6):491-8. doi: 10.1016/j.stemcr.2013.10.011. (2013)
Mertens, J., Stüber, K., Poppe, D., Doerr, J., Ladewig, J., Brüstle, O., Koch, P. „Embryonic stem cell-based modeling of tau pathology in human neurons“ Am J Pathol 182(5):1769-1779 (2013)
Koch, P., Taboli, I., Mertens, J., Ladewig, J., Stüber, K., Brüstle., O., Walter, J. “Presenilin-1 L166P ‘Mutant Human Pluripotent Stem Cell-Derived Neurons Exhibit Partial Loss of γ-Secretase Activity in Endogenous Amyloid-ß Generation’ Am J Pathol. 180(6):2404-2416 (2012)


Art des Bewerbungszugangs
Kontakt f├╝r Bewerbungen

PD Dr. med. Philipp Koch
Institute of Reconstructive Neurobiology
University of Bonn
Sigmund-Freud-Strasse 25
53127 Bonn
Tel. +49-228-6885-548

Details der Stellenanzeige

Befristete Anstellung
Berufserfahrung nicht vorausgesetzt
Deutschland (Nordrhein-Westfalen)
53127 Bonn
Biologie & Life Sciences, Healthcare & Gesundheitswesen