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Scientist for PhD Thesis: Genome Instability in Health and Disease

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We offer a position for a highly motivated Ph.D. student with great interest in bio-medical basic research focussing on genome instability in human disease.

 
Our research topic:
Several human diseases including neurodegenerative diseases and cancer are frequently associated with genome abnormalities. These include both, numerical and structural chromosome defects. One phenotype, which is in particular relevant, is the presence of aneuploidy, i.e. numerical chromosome abnormalities. For example, in cancer it is clear that aneuploidy can directly and significantly contribute to tumorigenesis, tumor progression and to the development of therapy resistance.
 
However, the molecular mechanisms leading to chromosome missegregation during mitotic cell division are little understood. Therefore, we aim to understand how chromosomes are missegregated during mitosis, which will eventually lead to the development of therapeutic strategies that can be used to suppress genome instability in human diseases.
 
 
The PhD project:
We recently discovered that abnormal cytoskeletal regulation (microtubules and actin) during mitosis are key to chromosome missegregation in mitosis (see our recent publications). We will use cell biological, biochemical and various (live cell) microscopy methods to investigate how abnormal microtubule and actin regulation causes chromosome missegregation during mitosis.
 
Relevant Publications (selection):
Ertych, N., Stolz, A., Stenzinger, A., Weichert, W., Kaulfuß, S., Burfeind, P., Aigner, A., Wordeman, L. und Bastians, H. (2014). Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells. Nature Cell Biology, 16: 779 – 791.
 
Stolz, A., Ertych, N., Kienitz, A., Vogel, C., Schneider, V., Fritz, B., Jacob, R., Dittmar, G., Weichert, W., Petersen, I. und Bastians, H. (2010). The CHK2-BRCA1 tumor suppressor pathway ensures chromosomal stability in human somatic cells. Nature Cell Biology 12: 492 – 499.
 
Stolz, A., Neufeld, K., Ertych, N. und Bastians, H. (2015). Wnt mediated protein stabilization ensures proper mitotic microtubule assembly and chromosomal stability. EMBO Reports, 16: 490-499.

Ertych, N., Stolz, A., Valerius, O., Braus, G.H. und Bastians, H. (2016). The CHK2-BRCA1 tumor suppressor axis restrains oncogenic AURORA-A to ensure proper mitotic microtubule assembly. Proc. Nat. Acad. Sci. USA, in press.

Techniques to be used:
We are using a wide spectrum of cell biological, molecular biological and biochemical methods and we are using human tissue culture cells as a model system and a particular methodological focus is on various microscopy techniques including deconvolution and confocal microscopy as well as life cell microscopy to follow the progression of mitotic cell division in living cells.
 
Our laboratory was newly established at the Göttingen Center for Molecular Biosciences and is part of the Göttingen Comprehensive Cancer Center (G-CCC). The Göttingen Center for Molecular Biosciences (GZMB) is a joint initiative of more than 30 molecular biology research groups. Major goals of the GZMB are fostering interdisciplinary research activities, utilizing high-end technologies, supporting young scientists and an integrated student teaching approach by a wide spectrum of faculty.

Our lab provides brand new lab space and state-of-the-art lab equipment in a highly stimulating scientific environment. PhD candidates will be given the chance to apply to the Göttingen Graduate School for Neurosciences and Molecular Biosciences, which is funded by the German Excellence Initiative (GGNB; see: www.uni-goettingen.de/en/sh/56640.html).
 
 
Requirements for the project:
Applicants for a Ph.D. student position should hold a MSc degree in molecular medicine, human biology, molecular biology, biochemistry, biology or related disciplines with a strong background in molecular/cell biology/biochemistry. Laboratory experience and a sound knowledge of biochemical and molecular biological techniques as well as experience with human cell culture is desired. The position is fully funded according to TL-V for 3-4 years. Start of the project will be discussed.

If you are interested in joining our lab please send your complete application including CV, list of publications and a brief summary of the previous research experience and interests and the names and addresses of at least two referees via EMAIL (as a single pdf file) to:
Prof. Dr. rer.nat. Holger Bastians: holger.bastians@uni-goettingen.de

Kontaktdaten


Art des Bewerbungszugangs
If you are interested in joing our lab please send your complete application including CV, list of publications and a brief summary of the previous research experience and interests and the names and addresses of at least two referees via EMAIL (as a single pdf file) to:
Prof. Dr. rer.nat. Holger Bastians: holger.bastians@uni-goettingen.de
Kontakt für Bewerbungen
Prof. Dr. rer.nat. Holger Bastians: holger.bastians@uni-goettingen.de

Details der Stellenanzeige


Arbeitszeit
Vollzeit
Vertragslaufzeit
Befristete Anstellung
Stellentyp
Promotionsstelle
Berufserfahrung
Berufserfahrung nicht vorausgesetzt
Region
Deutschland (Niedersachsen)
Arbeitsort
37077 Göttingen
Fachgebiet
Biologie & Life Sciences, Biotechnologie
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