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Master Thesis Position - Tangential flow-filtration of influenza virus feed streams for vaccine production

The global impact of influenza drives continuous efforts in R&D of vaccine manufacturing processes. Tangential flow filtration (TFF) can be used in several stages of the purification train for contaminant removal, concentration of feed streams and buffer exchange. In the scope of this project, different TFF matrices will be characterized and compared. The main goal is to identify how molecular weight cut-off (MWCO) and matrix material influence the performance of TFF in concentration and buffer exchange of an influenza virus feed stream.
 
Project tenor
  • Characterization of TFF matrices (determination of MWCO);
  • Comparison of the TFF matrices performance (productivity, recovery, purity);
  • Process analytics using different assays (for virus, DNA and protein)Optimization of concentration conditions)
 
Requirements
  •  Bachelors with a degree in biotechnology, biosystems engineering, or similar fields;
  •  Good communication skills in English, oral and written (international supervision);
  •  Self initiative and autonomous work.
 
The position is intended to start in the beginning of the winter semester 2016/2017 (approx. September).
 
How to apply:
E-mail: fortuna@mpi-magdeburg.mpg.de
Kontakt für Bewerbungen
Prospective parties direct questions and applications to:
A. Raquel Fortuna, MSc.
Phone: +49 391 6754674                                                                                                                                                           
E-mail: fortuna@mpi-magdeburg.mpg.de
Internet: www.mpi-magdeburg.mpg.de
 
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Über Max Planck Institute for Dynamics of Complex Technical Systems

In 1996 the Max Planck Institute for Dynamics of Complex Technical Systems was established. The foundation director is Prof. em. Dr.-Ing. Ernst Dieter Gilles. The institute in Magdeburg is the first institute of the Max Planck Society dedicated to the engineering sciences and is supposed to bridge the gap between basic research and industrial applications. The neighbourhood to the Otto...

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