Project for bachelor-thesis (Starting October 2015) Research group of Bioprocess Engineering
Project for bachelor-thesis
(Starting October 2015)
Research group of Bioprocess Engineering
Max-Planck-Institute for Dynamics of Complex Technical Systems Magdeburg
„Optimization of process parameters for the perfusion-based cultivation of an animal cell line using a tangential flow filtration (TFF) system“
Cell cultivation in perfusion mode consists in the continuous addition of nutrients at the same flow rate that exhausted medium enriched with the product of interest is extracted from the bioreactor. During perfusion, cells are contained within the bioreactor using a retention system, which enables to reach very high cell and product concentrations. The TFF-based retention system has proved its suitability to reach very high cell concentrations. However, operation parameters for tangential filtration should be set according to each cell line.
Within this project, optimal filtration parameters such as transmembrane pressure, flow rate and linear velocity, using a TFF-based perfusion system, should be established to minimize shear stress on an animal cell line. Optimal conditions should be used in further cultivations to achieve high cell concentrations.
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Complex Technical Systems Magdeburg
MSc. Daniel Vazquez
Tel.: 0391-6110 333
Details der Stellenanzeige
Über Max Planck Institute for Dynamics of Complex Technical Systems
In 1996 the Max Planck Institute for Dynamics of Complex Technical Systems was established. The foundation director is Prof. em. Dr.-Ing. Ernst Dieter Gilles. The institute in Magdeburg is the first institute of the Max Planck Society dedicated to the engineering sciences and is supposed to bridge the gap between basic research and industrial applications. The neighbourhood to the Otto...Mehr über die Max Planck Institute for Dynamics of Complex Technical Systems