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PhD Candidate on Biocatalytic cascade reactions - The Netherlands

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The BIOCASCADES Innovative Training Network for European Industrial Doctorates (ITN-EID) is an interdisciplinary research training network of 7 universities and 5 industrial enterprises from 5 European countries.  It is funded under the “Excellent Science” cluster of the EU’s Horizon 2020 program.  BIOCASCADES aims to develop the ESRs’ scientific expertise to produce excellent research, interdisciplinary collaboration with scientists from different fields (biology, chemistry and engineering) and entrepreneurship. 

 Roles and Responsibilities 

As an ESR you will work with two supervisors (academic and industrial) on your specific research project. Your PhD degree will be awarded on the basis of successful completion of the research work. The main part of your work will be carried out at DSM BV, and a secondment placement will be continued at Ruhr University Bochum, who are members of the BIOCASCADES network.
You will also be required to participate in the training and workshop organized by the ITN-EID.  As a Marie Skłodowska-Curie Actions fellow, you are also expected to contribute your time in the dissemination of your project’s result through public engagement and other scientific platforms.

Topic: Flow chemistry for synthesis of enantiopure 1,3/1,4-hydroxyaminoacids from prochiral ketoacids

In the first part of the project, the ESR is seconded to RUB for Assembly of a new two-enzyme cascade with in situ cofactor (alpha-ketoglutarate) generation from inexpensive L-Glu. The ESR will be introduced to the handling of the AAHs and clone a series of novel hydroxylases with 3- and 4-specificity. At DSM, the ESR will investigate different enzyme formulations (cell-free extract, growing cells, resting cells and immobilized enzyme) and proprietary fermentation methods from DSM for the conversion of commercially interesting branched-chain amino acids. 

The ideal candidate 
  • The applicant should have completed at least four or five years education with a Master’s degree or Diploma from a recognized university in Biochemistry, Chemistry, Biotechnology or Biology and should be eligible as graduate student at Ruhr University Bochum.
  • The applicant should have research experience in working with enzymes, biocatalysis, protein engineering, structural biology, organic synthesis or a related field. Expertise in molecular biology, organic synthesis and instrumental analytics is welcome.
  • The applicant should show interest in conducting a research project independently and should enjoy the work in an international, interdisciplinary environment.
  • At the time of recruitment, the applicant must not have resided (or carried out his/her main activity e.g. work, studies, etc.) in Netherlands, for more than 12 months in the last 3 years immediately prior to the reference recruitment date.
  • The applicant should have an excellent command of the English language at a proficient level (spoken and written) and the willingness to learn the local language of the recruiting country.
  • Background in general laboratory skills.
We emphasize equal opportunities in the biotechnology sector. We support the applications of female candidates in areas where they are underrepresented and encourage female candidates to apply for this program. Also, applications from handicapped candidates are very welcome.


Art des Bewerbungszugangs
To apply for the position, kindly provide: (i) a letter of motivation AND a 1-page statement of your research interests, relevant skills and experience; (ii) a CV including publication list; and (iii) names and contact details of three referees willing to write confidential letters of recommendation.  All materials should be attached as a single PDF file (max. size 4MB).  The PDF file name should include your first name and last name.

The closing date for all applications is 30th January 2015.

Send your applications to:
Kontakt für Bewerbungen
Dr. Martin Schürmann

Details der Stellenanzeige

Befristete Anstellung
Berufserfahrung nicht vorausgesetzt
6118 Geleen
Biotechnologie, Biologie & Life Sciences, Chemie