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PhD Thesis in Bio-(inorganic) Chemistry on: Self-Assembly and Metal-binding of the Amyloid-beta Peptide

 University of Strasbourg  67000 Strassburg
Place: Institut de Chimie (UMR 7177), 4 rue B. Pascal, 67000 Strasbourg (France)
Group: Biometals and Biological Chemistry
Groupleader and supervisor: Peter Faller
Profile: PhD Position at interface chemistry-biology: We are looking for a candidate with a background in chemistry, biological chemistry or biochemistry to perform a PhD project at the interface of (inorganic chemistry) with biology.
Eligibility: The candidate should have performed his studies until the bachelor outside Strasbourg (national or international), students doing only Master in Strasbourg are eligible.  
Project: There is a large body of evidence from In vivo, in cellulo and in vitro experiments that metal ions (mostly Cu, Zn and Fe) play an important role in the development of Alzheimer’s disease (AD). Cu and Zn ions are found in high concentration in the amyloid plaques, a hallmark of AD. These metal ions are bound to the peptide called amyloid-beta (Aβ), which is the major component of these plaques and are present in an aggregated form. Metal ions were reported to intervene in two key processes of Alzheimer’s disease: the aggregation of the peptide amyloid-β (Aβ) (mainly Cu and Zn) and the production of reactive oxygen species (ROS) (for Cu and Fe). Compounds that counteract the metal imbalance were reported to be a promising therapeutical approach.
The objective of the project is to elucidate the role of metal ions in the aggregation of Aβ. We plan to generate Aβ peptides labeled by different fluorophores in order to probe metal-binding, aggregation and interaction with different metalloproteins in the full-length Aβ under biologically relevant conditions.
Techniques: chemical and biochemical methods; spectroscopy (NMR, fluorescence, FTIR, etc), microscopy (AFM, TEM), chromatography; electrophoreses; cell culture and fluorescence microscopy
Key words: biometals; bioinorganic chemistry; copper, zinc; reactive oxygen species, self-assembly; amyloids; metal trafficking; fluorophores; spectroscopies.
Recent reviews of the group:
- Nasica-Labouze J, et al. Chem Rev. 2015, 115, 3518-63.
- Faller P, et al. Acc Chem Res. 2014, 47,2252-9.
Envisaged job starting date: 01/10/2016
Contact: Peter Faller, pfaller@unistra.fr
Application dead-line: 30 May 2016
Application instructions:
http://www.unistra.fr/index.php?id=22338 (see bottom for english version)
Group Website: http://institut-chimie.unistra.fr/equipes-de-recherche/bcb-biometaux-et-chimie-biologique/
How to apply:
by email
Kontakt für Bewerbungen
Peter Faller
Biometals and Biological Chemistry
Institut de Chimie UMR 7177
Université de Strasbourg
Le Bel 8eme etage
4, rue B. Pascal
67081 Strasbourg France
Tel.: +33 (0)3 68 85 69 49
email: pfaller@unistra.fr
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