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Das Bundesinstitut für Risikobewertung (BfR) ist das nationale Institut, das auf der Grundlage international anerkannter wissenschaftlicher Bewertungskriterien Gutachten und Stellungnahmen zu Fragen der Lebensmittel-, Futtermittel- und Chemikaliensicherheit und des gesundheitlichen Verbraucherschutzes erstellt. In diesen Bereichen berät es die Bundesregierung sowie andere Institutionen und Interessengruppen. Das BfR betreibt eigene Forschung zu Themen, die in engem Zusammenhang mit seinen Bewertungsaufgaben stehen. Es ist eine rechtsfähige Anstalt im Geschäftsbereich des Bundesministeriums für Ernährung, Landwirtschaft und Verbraucherschutz (BMELV). In der Abteilung Biologische Sicherheit des BfR ist ab 01.06.2013, vorbehaltlich der Mittelfreigabe, befristet für 3 Jahre die Stelle einer/eines Doktorandin / Doktorand - Entgeltgruppe 13 TVöD - Kennziffer: 1064/2013 mit 50 % der regelmäßigen wöchentlichen Arbeitszeit (z. Zt. 19,50 Std.) zu besetzen. Bis zum In-Kraft-Treten der neuen Entgeltordnung ist die Eingruppierung vorläufig. Die Befristung erfolgt auf Grundlage des Wissenschaftszeitvertragsgesetzes. Die Beschäftigung erfolgt im Rahmen eines Drittmittelforschungsprojektes im geplanten Verbundprojekt „Zoonosen und Lebensmittelsicherheit entlang globaler Warenketten“. Aufgaben: Die Tätigkeiten in der Fachgruppe „Hygiene und Mikrobiologie“ umfassen im Einzelnen: Mitarbeit bei der Entwicklung und Optimierung molekulardiagnostischer Testverfahren (FISH, PCR, etc.) für den Nachweis zoonotischer Erreger in Lebensmittelmatrices Entwicklung neuer Extraktionsmethoden für Lebensmittelmatrices Bakterielle Spezialdiagnostik in Lebensmitteln Wissenschaftliche Auswertung der erhobenen Daten Verfassen wissenschaftlicher Manuskripte bis zur Publikationsreife und Präsentation von Studienergebnissen auf nationalen und internationalen Kongressen Mitarbeit bei der Wartung der regelmäßig genutzten Laborgeräte (insbesondere PCR, Thermoycler, ELISA Reader, Pipetten, Mikroskope u. a.) Durchführung von Qualitätssicherungsmaßnahmen für die o. g. experimentellen Untersuchungen Anforderungen: Abgeschlossenes Hochschulstudium der Medizin, Veterinärmedizin oder einer anderen naturwissenschaftlichen Disziplin (Chemie, Biotechnologie, Hygiene, Mikrobiologie etc.) Mikrobiologische Vorkenntnisse und praktische Erfahrungen im mikrobiologischen Labor sind erforderlich Kenntnisse zu relevanten zoonotischen Mikroorganismen bei Tieren und in Lebensmitteln Bereitschaft zum Umgang mit pathogenen Agenzien (bakteriellen Erregern) bis zur Sicherheitsstufe S2 Sehr gute Kenntnisse der englischen Sprache in Wort und Schrift erforderlich Gute EDV-Kenntnisse sowie eine gewissenhafte Arbeitsweise, Flexibilität, Teamfähigkeit und Belastbarkeit werden vorausgesetzt Der Dienstort ist Berlin. Nähere Auskünfte erteilen Herr PD Dr. Al Dahouk (Tel.: 0 30 - 1 84 12 - 12 44; Email: Sascha.Al-Dahouk@bfr.bund.de) und Herr Prof. Dr. Appel (Tel.: 0 30 - 1 84 12 - 21 53). Richten Sie bitte Ihre Bewerbung mit vollständigen Unterlagen (E-Mail-Bewerbungen können nicht berücksichtigt werden) unter Angabe der Kennziffer 1064/2013 bis zum 29. Mai 2013 an das Bundesinstitut für Risikobewertung, Personalreferat - 11.17 -, Max-Dohrn-Str. 8-10, 10589 Berlin. Das BfR begrüßt Bewerbungen von Menschen aller Nationalitäten. Als innovative wissenschaftliche Einrichtung bietet das BfR familienfreundliche Arbeitsbedingungen. Dafür wurde das BfR im April 2009 mit dem Zertifikat „audit berufundfamilie®“ ausgezeichnet. Das BfR gewährleistet die berufliche Gleichstellung von Frauen und Männern. An der Bewerbung von Frauen besteht daher ein besonderes Interesse. Schwerbehinderte Menschen werden bei gleicher Eignung besonders berücksichtigt; von ihnen wird nur ein Mindestmaß an körperlicher Eignung verlangt.


(im Bereich Forschung & Entwicklung, Forschung & Lehre)

iGRASP seed , the launch of an international graduate school of protein science and technology, now offers new scholarship projects at Heinrich Heine University Düsseldorf and the co-operating Forschungszentrum Jülich GmbH in Germany. Start of the scholarships is variable. Scholarships will be funded with 1,400 Euro per month for 3 years.   The novel graduate school iGRASP seed stands for innovative and all-embracing doctoral education and research in the wide field of protein science and technology. Within a very stimulating and tight network all projects include aspects of biotechnology, structural biology, and beyond.   Highly motivated and excellent young scientists holding a recent MSc, MA, Magister, or German Diploma degree (5 years of university education) in Biochemistry, Biotechnology, Biology, Biophysics, Chemistry, Bioinformatics, or related disciplines can now apply for one of the scholarships chosen out of the research projects described in detail on our website: www.iGRASP.de.    The multifarious topics include inter alia : structure-function characterization of various metabolic enzymes, chaperones, or proteins linked to human diseases, optimization and application of biocatalysts, photoreceptor systems, substrate recognition processes.   For further information on the program, possible doctoral (PhD) research projects, prerequisites and the application instructions please visit our homepage:   www.iGRASP.de Applicants must be fluent in written and spoken English as demonstrated by high scores in TOEFL, IELTS or comparable tests. Knowledge of German is highly desirable.


(im Bereich Forschung & Lehre)

The Cluster of Excellence RESOLV ( R uhr E xplores Solv ation), in conjunction with the newly founded Graduate School of Solvation Science (GSS), is looking for top-class graduate students with an interest in the field of solvation science .   The candidates should have a first-class Master’s Degree (or equivalent) in chemistry, physics, biochemistry, engineering, or a related discipline. Our Graduate Program offers a 3-year course that combines cutting-edge research with a structured curriculum of lectures, colloquia, and workshops centered on all areas of solvation science.   All GSS courses are held in the English language.   RESOLV is funded within the German Excellence Initiative and aims at establishing “Solvation Science” as an overarching topic at the Ruhr Universität Bochum. The mission of RESOLV is to launch Solvation Science as a new interdisciplinary field to understand the influence of solvation on reactions, the function of biomolecules, and processes at liquid-solid interfaces. RESOLV aims to create an interdisciplinary framework for understanding solvent processes that is universal and adds a predictive capability.   Please refer to our website www.rub.de/solvation for more details of the departments participating in the RESOLV cluster and their particular research areas.   The Ruhr-Universität Bochum is an equal opportunities employer.


(im Bereich Forschung & Lehre, Wissenschaftl. MitarbeiterIn)

We are seeking highly motivated individuals with a M.Sc. or Diploma degree who would like to conduct the research for their PhD thesis in our lab (about 3 years, $28,500/year). The student can pick the starting date. Our labs studies protein folding both in the test tube and in the cell.  We aim to understand protein folding well enough to be able to manipulate it. We ask organisms themselves to solve protein folding problems. By examining their solutions we can better understand folding in the cell. We have developed folding biosensors that link protein stability to antibiotic resistance. They enable us to optimize folding in vivo (1) and discover new molecular chaperones (2). Protein folding in the cell is intimately tied to the action of folding catalysts and chaperones. We study the action of these folding helpers both in vivo and in vitro using a wide range of genetic, biochemical, biophysical and structural techniques (2,3). We have a lot of experience working with German graduate, master and diploma students and can help with the paperwork. Our lab is located at the University of Michigan, one of top five public schools in the country, which provides an excellent research environment. 1. Foit L et al (2009) Optimizing protein stability in vivo. Mol Cell 36: 861-871. 2. Quan et.al. (2011) Genetic selection designed to stabilize proteins uncovers a  chaperone called Spy. Nature Struct. Mol. Biol.18(3):262-9 3. Foit L et al. (2011) Chaperone activation by unfolding. PNAS 110(14):E1254-62.


(im Bereich Forschung & Entwicklung, Forschung & Lehre)

In the field of “ Branched cell penetrating peptides as control and delivery molecules for transcription factors ” the research group of Dr. Kalina Peneva at Max Planck Institute for Polymer Research   offers a PhD project. Description: We propose the design and synthesis of new and improved inhibitors of nuclear factor kappa light chain enhancer (NF-κB) transcription factor. This new approach is based on branched peptide sequences in combination with small organic molecule and non-natural amino acids. Numerous studies have shown that NF-κB deregulation is an abnormality in many cancer types and this constitutive activation of NF-κB has been directly associated in tumor genesis, invasion, metastasis and foremost in the escape of cancer cells from programed cell death. Additionally, resistance of cancer cells to chemotherapeutic agents can be partially explained by deregulated NF-κB activation, therefore NF-κB signaling pathway can be considered as a prime target for cancer therapy and drug development. The development of new peptide drugs has been largely limited by their short half-life due to proteolitic cleavage. Branched peptides have not only shown strong resistance to proteases and peptidases, but they can also enable multivalent molecules with a defined chemical structure to be constructed. Cell penetrating peptides (CPP) carrying a functional cargo will be utilized to control signal transduction-dependent subcellular traffic of transcription factors mediating the cellular response to different agonists. Different CPPs will be applied, in order to test their uptake depending on the point of conjugation, branching, number of charges and hydrophobicity. Small organic molecules – namely inhibitors for NF-kB like bortezomib or olmesartan will be coupled to the delivery vehicle. These functional delivery systems will allow us to study the influence of peptide concentration; charge density and the importance of the multiple interactions, over the efficiency, uptake and distribution of the drug, in order to create new inhibitors for NF-kB. We offer The possibility to work on a cutting-edge project using state-of-the-art technology in a highly motivated research team A stimulating, diverse and international research environment Advanced training opportunities A competitive stipend   Required qualifications Master or Diploma Motivation to solve complex biological problems Excellent communication skills   Starting date: 1 October 2013 or later Duration of stipend: 3 years, with the possibility of extension Deadline for applications (exclusively online via web form):  1 July 2013 


(im Bereich Forschung & Entwicklung, Forschung & Lehre)

PhD Position – Membrane Complexes in Adaptive Immunity Institute of Biochemistry, Biocenter, Goethe-University Frankfurt   A PhD position is available for highly motivated candidates to join a research group interested in investigating the structure and mechanism of multisubunit complexes involved in immunity, virus, and tumor escape. The position (E13/50-65%) is embedded in a dynamic and international research environment on membrane biology, including the Cluster of Excellence on Macromolecular Complexes (www.cef-mc.de) and the Collaborative Research Center on Membrane Transport and Communication (www.sfb807.de). The candidate will be part of an excellent integrated research training group ‘TRAM’ (http://www.sfb807.de/mgk.html). Highly motivated and competent candidates with background in biochemistry, biology, biophysics, chemistry, or a closely related field are encouraged to apply. The candidate should have demonstrated creative thinking, be able to work independently and collaboratively. Interested applicants are to send an application containing CV, a summary of past research experience, summary of Bachelor, Master, or Diploma courses as well as names/contact information of two references to: Robert Tampé, Institute of Biochemistry, Goethe-University Frankfurt, Max-von-Laue-Str. 9, 60438 (appl.sfb807@em.uni-frankfurt.de).


(im Bereich Forschung & Lehre)

In the context of a common project with the Univerity Lübeck funded by the center of excellence "Inflammation of interfaces" we offer a PhD position for three years entitled " Protease-mediated modulation of inflammation-induced vascular pathology in Alzheimer’s Disease". We are looking for highly motivated, talented and well qualified applicants with interest in fundamental research related to clinical aspects such as neurodegenerative alterations in Alzheimer Disease. A full application including CV, references, publications and documentation of achievements should be send by email.


(im Bereich Forschung & Entwicklung, Forschung & Lehre, Klinische Forschung, Wissenschaftl. MitarbeiterIn)

We are looking for highly motivated PhD students with a background in bio­chemistry and molecular biology. We have identified a positive feedback loop connecting the oncogene c-MYC and the deacetylase SIRT1 (Menssen, A. PNAS USA 2012 Jan 24; 109(4):E187-96). In the thesis project components of the feedback loop will be subject to further analysis for their contribution to common traits of cancers like immortalization, transformation, tumor metabolism and intercellular signaling between cancer and stromal cells.


(im Bereich Forschung & Entwicklung, Wissenschaftl. MitarbeiterIn)

The international PhD program of the Berlin-Brandenburg School for Regenerative Therapies (BSRT) offers outstanding interdisciplinary training and research opportunities for graduates of biolocial sciences who want to pursue a career in the field of Regenerative Medicine and aim at translating their scientific discoveries into clinical applications. The BSRT is a collaboration between the Charité- Universi­tätsmedizin Berlin, the Humboldt-Universität zu Berlin, the Freie Universität Berlin, the Technische Universität Berlin, the Universität Potsdam, Max Planck Institute for Molecular Genetics, Max Delbrück Center for Molecular Medicine, Deutsches Rheumaforschungszentrum, Deutsches Herz­zentrum Berlin and other high-ranking research institutions in Berlin and Brandenburg. This collaboration offers top class scientific training during the doctoral project. Requirements are a Master’s or equivalent degree in biology, biochemistry, bioengineering, immunology and veterinary medicine. The doctoral program will start in November 2013 Application deadline is the 20th June 2013 Successful candidates who will study for their doctoral degree at the BSRT will be either funded by the BSRT or through third party funding of the group where they do their scientific research. The BSRT is an equal opportunities Graduate school. We particularly encourage applications from women. We also welcome applications from disabled persons and the BSRT operates a policy whereby preference is given to disabled applicants who have qualifications equivalent to those of able bodied persons applying for the same position.


(im Bereich Forschung & Lehre, Wissenschaftl. MitarbeiterIn)

In our group of Physical Chemistry / Molecular Material Science (Physikalische Chemie / Molekulare Materialwissenschaften at the Institut für Chemie at the Technische Universität Berlin (TU Berlin, Germany) we have currently an opening for a three-year PhD position (funding: 2/3 E13) funded by the DFG (Deutsche Forschungsgemeinschaft) on the topic of Shaping of Nanotubules Formed by Amino Acid Amphiphiles This project is concerned with an in-depth investigation of the formation of selfassembled nanotubes made of peptide-mimetic amphiphiles (amino acid amphiphiles, AAAs), and involves molecular design and synthesis as well as the structural characterisation of their aggregates. The main focus will be on the formation of nanotubuli by these peptide amphiphiles as they constitute novel well-defined materials of high interest for purposes of drug delivery but also their formation is of fundamental interest for the understanding of several diseases, e.g. Alzheimers. It is a joint project with the group of Prof. Dganit Danino (Technion, Haifa, Israel), where the synthesis will be done by both groups in a complementary way. The main part will be the systematic structural characterisation, mainly to be done on the TU side by light, x-ray, and neutron scattering and by the Technion side by means of cryogenic-transmission electron microscopy (cryo-TEM). The Ph.D. position on the TU side shall be for a chemist or physicist having comprehensive expertise in the field of preparation and characterization of colloidal systems. He/she shall perform the experimental research work with a particular emphasis on the mesoscopic characterization of the nanotubes and their formation process by means of scattering methods (SLS, DLS, SAXS, SANS) and fluorescence microscopy and fluorescence correlation spectroscopy (FCS). In addition he/she will work on the effects of incorporating amphiphilic copolymers into the nanotubes and thereby exerting structural and stability control by this way. Within the period of the Ph. D. work also two or three visits to the partner institute in Israel are foreseen in order to ensure close cooperation and becoming acquainted with the cryo-TEM technique.


(im Bereich Forschung & Entwicklung, Wissenschaftl. MitarbeiterIn)

Applications are invited for a PhD position in the design, expression, purification and characterization of proteins in the GPI and Glycoproteins group, department of Biomolecular Systems at the Max Planck Institute of Colloids and Interfaces in Berlin. The successful candidate will work on the molecular biology (cloning, expression and purification) of proteins in bacterial and/or yeast expression systems and the application of the expressed molecules for the semi-synthesis of glycoproteins and GPI-anchored proteins by ligation with synthetic materials (Peptides, carbohydrates, glycolipids) Candidates should be highly motivated, enthusiastic, with an ability to think creatively and work independently as well as in an interdisciplinary scientific environment. Experience in working with inteins, protein biochemistry and protein characterization methods (mass spectrometry, HPLC, etc.), chemical biology and other biochemistry techniques will be positively evaluated. Good English communications skills are necessary. The position is for a 3 years project. To apply, please send a cover letter summarizing your past experience, research interests and career goals and CV including the names and contact information of 2-3 references.


(im Bereich Wissenschaftl. MitarbeiterIn)

The Graduate School of Excellence 'JSMC' invites applications for a Doctoral Researcher Position TV-L E13 65% (Ref.No. 85/2012) to conduct research on the project Control of heavy metal resistance genes in Streptomyces   Streptomycetes - soil living bacteria forming aerial mycelium with spores - are used to determine the mechanisms of heavy metal resistance. The basis of this research is a streptomycete strain collection and the isolation of new strains from different heavy metal contaminated areas like the former uranium mining site Wismut in Eastern Thuringia, Germany. For the study of candidate genes, an effective transformation system needs to be developed within isolates from a test field site operated by the university since 2004 in the former uranium mining site in Eastern Thuringia.   More projects details: www.jsmc.uni-jena.de/phd-program/fellowship-application/vacant-projects/   We expect: a Master's degree (or equivalent) in Natural Sciences. Candidates about to earn their degree are welcome to apply. high motivation and interest to join one of the interdisciplinary research areas of JSMC creativity and interest to shape your own thesis project an integrative and cooperative personality with enthusiasm for actively participating in the lively JSMC Community very good communication skills in English (instruction language at JSMC) We offer: a highly communicative atmosphere within a scientific network providing top-level research facilities a doctoral researcher position (TV-L E13, 65%) funded for three years based on the regulations of the German Research Foundation as well as generous research funding a comprehensive mentoring program with supervision by a team of advisors a top-level PhD training program with courses in state-of-the-art research technologies and soft skills Jena - the German City of Science 2008: a young and lively town with dynamic business activities, successful scientific centers of innovation and a vibrant cultural scene around the famous Friedrich Schiller University Friedrich Schiller University Jena is an equal opportunity employer. The application procedure takes place exclusively online via the JSMC website:   www.jsmc.uni-jena.de   Please acquaint yourself with the open PhD projects and the application process described on this website.   Selected applicants will be invited to the JSMC Recruitment Meeting in Jena, Germany (at the end of June/beginning of July). Awarding decisions will be made shortly thereafter, allowing the projects to start immediately.   Application deadline: May 1st, 2013 (12pm, CET)


(im Bereich Forschung & Entwicklung, Forschung & Lehre)

The Graduate School of Excellence 'JSMC' invites applications for a Doctoral Researcher Position TV-L E13 65% (Ref.No. 88/2013) to conduct research on the project Chemical communication between biotrophic and necrotrophic pathogens and a woody plant host: Signaling, defense reactions, and the cost of defense   The interactions between black poplar (P. nigra) and its two most important pathogens, the biotrophic poplar rust (Melampsora larici-populina) and the necrotrophic poplar canker (Cryptodiaporthe populea) will be compared. The goal is to understand the differences in the biosynthesis of chemical defense compounds of P. nigra in response to biotrophic vs. necrotrophic pathogens, how this chemical defense affects the pathogens and the costs and benefits of such defenses.   More projects details: www.jsmc.uni-jena.de/phd-program/fellowship-application/vacant-projects/   We expect: a Master's degree (or equivalent) in Natural Sciences. Candidates about to earn their degree are welcome to apply. desirable methodological skills: basic knowledge of biochemical and microbiological methods, a willingness to learn analytical chemistry and to do experiments in the field. high motivation and interest to join one of the interdisciplinary research areas of JSMC creativity and interest to shape your own thesis project an integrative and cooperative personality with enthusiasm for actively participating in the lively JSMC Community very good communication skills in English (instruction language at JSMC) We offer: a highly communicative atmosphere within a scientific network providing top-level research facilities a doctoral researcher position (TV-L E13, 65%) funded for three years based on the regulations of the German Research Foundation as well as generous research funding a comprehensive mentoring program with supervision by a team of advisors a top-level PhD training program with courses in state-of-the-art research technologies and soft skills Jena - the German City of Science 2008: a young and lively town with dynamic business activities, successful scientific centers of innovation and a vibrant cultural scene around the famous Friedrich Schiller University Friedrich Schiller University Jena is an equal opportunity employer. The application procedure takes place exclusively online via the JSMC website:   www.jsmc.uni-jena.de   Please acquaint yourself with the open PhD projects and the application process described on this website.   Selected applicants will be invited to the JSMC Recruitment Meeting in Jena, Germany (at the end of June/beginning of July). Awarding decisions will be made shortly thereafter, allowing the projects to start immediately.   Application deadline: May 1st, 2013 (12pm, CET)


(im Bereich Forschung & Entwicklung, Forschung & Lehre)

The Graduate School of Excellence 'JSMC' invites applications for a Doctoral Researcher Position TV-L E13 65% (Ref.No. 90/2013) to conduct research on the project Interaction of freshwater acI Actinobacteria with its partners in enrichment cultures   Actinobacteria of the acI clade are ubiquitous and abundant in many lakes, yet there is no pure culture to date. We were able to obtain several stable co-cultures dominated by acI. Some of them will be the subject of metagenomic sequencing at the Joint Genome Institute (JGI) in California. The PhD student may spend some time at JGI to get familiar with the sequencing process and data analysis. The goal of this PhD project will be the characterization of these enrichments by various methods.   More projects details: www.jsmc.uni-jena.de/phd-program/fellowship-application/vacant-projects/   We expect: a Master's degree (or equivalent) in Natural Sciences (preferentially Microbiology). Candidates about to earn their degree are welcome to apply. desirable methodological skills: molecular biology, preferentially including qPCR, transcriptomics, DNA sequencing and sequence analysis, genomics, microscopy high motivation and interest to join one of the interdisciplinary research areas of JSMC creativity and interest to shape your own thesis project an integrative and cooperative personality with enthusiasm for actively participating in the lively JSMC Community very good communication skills in English (instruction language at JSMC) We offer: a highly communicative atmosphere within a scientific network providing top-level research facilities a doctoral researcher position (TV-L E13, 65%) funded for three years based on the regulations of the German Research Foundation as well as generous research funding a comprehensive mentoring program with supervision by a team of advisors a top-level PhD training program with courses in state-of-the-art research technologies and soft skills Jena - the German City of Science 2008: a young and lively town with dynamic business activities, successful scientific centers of innovation and a vibrant cultural scene around the famous Friedrich Schiller University Friedrich Schiller University Jena is an equal opportunity employer. The application procedure takes place exclusively online via the JSMC website:   www.jsmc.uni-jena.de   Please acquaint yourself with the open PhD projects and the application process described on this website.   Selected applicants will be invited to the JSMC Recruitment Meeting in Jena, Germany (at the end of June/beginning of July). Awarding decisions will be made shortly thereafter, allowing the projects to start immediately.   Application deadline: May 1st, 2013 (12pm, CET)


(im Bereich Forschung & Entwicklung, Forschung & Lehre)

The National Center for Tumor Diseases (NCT) Heidelberg offers a highly interactive and collaborative scientific environment with a strong focus on translational cancer research. Colorectal cancer (CRC) is the most frequent cause of cancer related death in the western world. Understanding the regulation of self-renewal and differentiation of tumor-initiating cells (TIC) in CRC is pivotally important to eradicate malignant stem cell-like cells in human cancer and to develop safe and efficient genetically modified stem cell therapeutics. We have shown recently that tumor-initiating cells within individual CRC patient samples functionally differ in their potential to self-renew and that distinct classes of TIC drive long-term tumor progression and metastasis formation. Only these rare self-renewing long-term TIC maintain long-term disease and form metastases. The interplay between functional and genetic heterogeneity is unknown. Currently we address the functional and molecular heterogeneity within the TIC compartment of primary human colon cancers to develop genotype based eradication strategies directed against this most relevant cell fraction. Successful PhD candidates will develop and validate molecular strategies specifically targeting the tumor-initiating cell compartment of human solid tumors.


(im Bereich Klinische Forschung, Forschung & Entwicklung, Wissenschaftl. MitarbeiterIn)

Aufgaben: Implementierung prozessanalytischer Methoden zur Prozess- und Qualitätsüberwachung im Bereich kontinuierlicher pharmazeutischer Produktion Mitarbeit an der Schnittstelle zwischen universitärer Forschung und Industrie/Wirtschaft und bei der Optimierung der Produkt- und Prozessentwicklung im Pharmabereich Anwendung statistischer Methoden zur Analyse spektroskopischer und generischer Messdaten Eigenständige Entwicklung von Messstrategien und Durchführung von Prozessanalysen Durchführung von Qualitäts- und Risikomanagement an pharmazeutischen Prozessen Dokumentation sowie Präsentation der Ergebnisse vor internen und externen Kunden Wissenschaftliche Publikationstätigkeit


(im Bereich Produktion, Qualitätssicherung/-management, Forschung & Entwicklung)

Das Helmholtz Zentrum München verfolgt als deutsches Forschungszentrum für Gesundheit und Umwelt das Ziel, personalisierte Medizin für die Diagnose, Therapie und Prävention weit verbreiteter Volkskrankheiten wie Diabetes mellitus und Lungenerkrankungen zu entwickeln. Wir sind Mitglied der Helmholtz-Gemeinschaft, der größten Wissenschaftsorganisation Deutschlands. Im internationalen Forschungsverbund des ''Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health'' (HICE) werden Effekte anthropogener Aerosole auf verschiedenen biologischen Ebenen mit modernsten analytischen Techniken untersucht, um detailliertere Aussagen über molekulare Wirkmechanismen zu erhalten. Im Rahmen dieses interdisziplinären Forschungsvorhabens sucht die Kooperationsgruppe ''Comprehensive Molecular Analytics'' zum nächstmöglichen Zeitpunkt eine/n Doktorand/in - Untersuchung des Einflusses von anthropogenen Aerosolen auf biologische Systeme 2013/1955 Ihre Aufgaben Entwicklung von chromatographischen und massenspektrometrischen Methoden zur Untersuchung von Zellsystemen Zellkultur und Probenvorbereitung Etablierung eines Zell-Expositionssystems, das die Exposition der Zielzellen mit luftgetragenen Stoffen direkt an der Luft/Zell-Grenzfläche erlaubt Planung und Durchführung von Zellexperimenten Durchführung der Analysen und Auswertung der Messergebnisse Verfassung von wissenschaftlichen Publikationen Teilnahme an europaweiten Messkampagnen Ihre Qualifikation Hochschulabschluss (Diplom, Master) in Chemie, Biochemie, Biologie mit dem Schwerpunkt bioanalytische Chemie praktische Erfahrungen im Labor sowie mit instrumentellen analytischen Methoden großes Interesse am wissenschaftlichen Arbeiten ausgeprägte Teamfähigkeit Unser Angebot Tätigkeit in einem innovativen, zukunftsorientierten Unternehmen umfangreiches Fortbildungsangebot zunächst für drei Jahre befristetes Arbeitsverhältnis und eine Vergütung nach TVöD (EG 13 50 %) Das Helmholtz Zentrum München als Träger des Bayerischen Frauenförderpreises sowie des Total E-Quality Zertifikates strebt eine Erhöhung des Frauenanteils an und fordert deshalb qualifizierte Interessentinnen auf, sich zu bewerben. Schwerbehinderte werden bei gleicher Eignung bevorzugt. Der Doktorand / die Doktorandin wird Mitglied der HELENA Graduiertenschule (http://www.helmholtz-helena.de/), einer gemeinsamen Initiative des Helmholtz Zentrums München und der Elite-Universitäten TUM und LMU, die ein breites Weiterbildungsprogramm anbieten.


(im Bereich Forschung & Lehre)

Das Universitätsklinikum Münster ist eines der führenden Krankenhäuser Deutschlands. Eine solche Position erlangt man nicht nur durch Größe und medizinische Erfolge. Wichtig ist das Engagement jedes Einzelnen. Wir brauchen Ihr Engagement, um selbst im Kleinen Großes für unsere Patienten leisten zu können. Dafür bieten wir Ihnen viele Möglichkeiten, damit Sie selbst weiter wachsen können. Wir suchen für das Institut für Experimentelle Muskuloskelettale Medizin (IEMM) zum nächstmöglichen Zeitpunkt, befristet für zunächst 3 Jahre mit der Möglichkeit der Verlängerung eine/n Doktorand / Doktoranden Fachrichtung Biologie, Biochemie, Humanmedizin oder Life Sciences Kennziffer 6546 Verg. je nach Qualifikation und Aufgabenübertragung bis Entgeltgruppe 13 TV-L (65%) im Rahmen einer durch die Deutsche Forschungsgemeinschaft (DFG) geförderten Emmy-Noether Nachwuchsgruppe. Schwerpunkt ist die Untersuchung matrixdegradierender Mechanismen und Signalübertragungen in Chondrozyten während der Osteoarthrose. Dabei untersuchen wir vor allem die Interaktion von WNT-Signalwegen mit transmembranen Heparansulfat-Proteoglykanen der Syndecan-Familie. Die Aufgabengebiete umfassen histologische, molekularbiologische und zellbiologische Untersuchungen, die Anwendung von Methoden des viralen und nicht-viralen Gentransfers sowie die Untersuchung an verschiedenen Mausmodellen.   Wir erwarten ein abgeschlossenes Studium in den oben genannten Fachrichtungen, Laborerfahrungen in Molekularbiologie und/oder Zellbiologie, Histologie und Tierexperimenten sind wünschenswert. Sehr gute Englischkenntnisse sind aufgrund der internationalen Teamstruktur erwünscht. Ausgewählte Literatur: Echtermeyer F, Bertrand J, Dreier R, Meinecke I, Neugebauer K, Fuerst M, Lee J, Song YW, Herzog C, Theilmeier G, Pap T. Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis. Nat Med. 15 :1072-1076 (2009) Bertrand J, Stange R, Hidding H, Echtermeyer F, Nalesso G, Godmann L, Timmen M, Bruckner P, Dell'accio F, Raschke MJ, Pap T, Dreier R. Bone fracture repair, but not fetal skeletal development is supported by syndecan-4. Arthritis Rheum. (2012) Bei Rückfragen wenden Sie sich bitte an Frau Dr. rer. nat. Jessica Bertrand (Tel +49-251-83-52974, e-mail: bertrand@uni-muenster.de) Institut für Experimentelle Muskuloskelettale Medizin. Es besteht grundsätzlich die Möglichkeit der Teilzeitbeschäftigung. Die Bewerbung von Frauen wird begrüßt; im Rahmen der gesetzlichen Vorschriften werden Frauen bevorzugt eingestellt. Schwerbehinderte werden bei gleicher Eignung besonders berücksichtigt. Diese und weitere Stellenausschreibungen des UKM finden Sie unter: www.ukmuenster.de


(im Bereich Forschung & Entwicklung, Forschung & Lehre, Klinische Forschung, Wissenschaftl. MitarbeiterIn)

We are interested in recruiting highly motivated and creative PhD students to study the fascinating molecular organization of biological membranes. Our lab takes an interdisciplinary approach to this topic, employing biochemical, biophysical, molecular biological and cell biological techniques. Our lab focuses on the in vitro reconstitution of cellular membrane systems. Specifically, we use recombinantly expressed proteins and purified native protein complexes in combination with model membrane systems, including planar lipid bilayers (single channel electrophysiology), giant unilamellar vesicles and supported bilayers. In vitro findings are then explored in appropriate cell biology systems. Students with an interest in biochemistry, molecular biology, biophysics and cell biology are encouraged to apply. We are a young and highly motivated group offering projects with a broad range of techniques and integration into the international research campus in Göttingen, Germany. Students will be integrated into a graduate school at the University of Göttingen. Interested candidates should send their applications including a CV with a possible publication list, the names and contact information of two references, and a motivation letter in a single file to: michael.meinecke@med.uni-goettingen.de http://www.uni-bc.gwdg.de/index.php?id=697


(im Bereich Forschung & Entwicklung, Forschung & Lehre)

You will be involved in our research focused on next generation molecular contrast agents for non-invasive neuroimaging of brain function and remote control systems for neuronal processes. Our research facilities at the University Hospital of Technische Universität München (http://www.tum.de/en/homepage/) and the collaborating Institute for Biological and Medical Imaging (IBMI, http://www.helmholtz-muenchen.de/en/ibmi/) are equipped with state-of the art imaging systems, including small animal MRI machines with a Hypersense DNP Polarizer, hybrid MRI/PET, PET/CT, Multispectral Optoacoustics, Bioluminescence, 2-P microscopy and optogenetics.


(im Bereich Klinische Forschung, Projektmanagement, Forschung & Entwicklung)