PhD position DKFZ/Heidelberg "The role of epigenetic modifiers in liver cancer plasticity"


The Helmholtz University group “Cell plasticity and Epigenetic Remodeling” (Head: Dr. Darjus Tschaharganeh) is seeking for highly motivated and ambitious PhD candidates. The related positions will be within the new established SFB/TRR209 “LIVER CANCER: New mechanistic and therapeutic concepts in a solid tumor model”. The project aims to define the role of epigenetic modifiers in liver tumorigenesis and liver cell plasticity.

The Project:
Our research group is a ambitious group of scientists located at the German Cancer Research Center (DKFZ) and Institute of Pathology at the University Hospital Heidelberg. We have strong expertise in functional-genomics screening technologies as well as murine models for liver cancer. The central goal of the project is to discover the role of epigenetic modifiers in liver cancer using powerful mouse models in vivo and subsequently identify potential vulnerabilities of genetic defined tumor cells for therapeutic target discovery. To this end the PhD student will use unique mouse model systems based on CRISPR/Cas9 genome editing and Tet-regulatable shRNA transgenic mouse strains as well as CRISPR/Cas9-based pooled library screens to dissect the role of epigenetic modifiers in liver cancer.

Required Qualifications:
We are seeking a highly motivated and ambitious PhD candidate, who wants to pursue research projects with creativity, independence and team spirit. Interest in techniques such as pooled library screens, mouse models of cancer or molecular biology are required. The applicant should work efficiently, be highly self-motivated and accurate. Excellent written and oral capabilities in English are essential. The candidate will be enrolled in the DKFZ International PhD program (http://www.dkfz.de/en/phd-program/index.html?m=1483624252).

Contact & Application:
If you are interested, please submit a cover letter, your CV, publication list, university degrees, contact details for at least two references in one pdf online to darjus-felix.tschaharganeh@med.uni-heidelberg.de .

Dr. Darjus Tschaharganeh
Cell Plasticity and Epigenetic Remodeling
Im Neuenheimer Feld 224
69120 Heidelberg
Phone: 06221 56-34555
darjus-felix.tschaharganeh@med.uni-heidelberg.de

http://www.dkfz.de/en/zellplastizitaet/index.php


Publishing date: May 29, 2017

We stand for equal opportunities. People with disabilities are given priority with the same suitability. The university hospital aims at a general increase in the proportion of women in all areas and positions where women are underrepresented. Qualified women are therefore particularly encouraged to apply.
Kontakt für Bewerbungen
Dr. Darjus Tschaharganeh
Cell Plasticity and Epigenetic Remodeling
Im Neuenheimer Feld 224
69120 Heidelberg
Phone: 06221 56-34555
darjus-felix.tschaharganeh@med.uni-heidelberg.de
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