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At the Faculty of Medicine, Institute for Lung Research, Young investigator Group” RNA-Biology of Inflammation and Infection”, Dr. Leon Schulte, we offer the position of a
 
PhD student

starting at 1th June 2015 for two years with the possibility of extension. Salary will be according to German Public Service (50 % TV-Hessen 13, with the possibility of a rise up to 65 % in the case of save financing).

The position will offer the possibility of further scientific qualification in the frame of the as-signed duties.

Scientific services belong to the duties in research and teaching. The candidate will take part in the International Graduate Programme “Molecular Biology and Medicine of the Lung (MBML)” and cooperate within the frame of the LOEWE-Cluster “Medical RNomics”. The emphasis of the pro-ject will be on Long non-coding RNAs in human lung innate immunity. LncRNAs constitute a novel, heterogeneous class of eukaryotic RNAs >200 nt in size, that do not encode proteins. We have recently identified dozens of lncRNA genes that are activated on challenge of human monocytes with bacterial immune agonists. Aim of the current research project is to elucidate the immune-regulatory functions of selected lncRNA in the human innate immune response to bacterial patho-gens of the respiratory system. To this end primary and immortalized human cell cultures will be challenged with the model pathogen Legionella pneumophila and lncRNAs expression changes will be monitored by RNA deep sequencing. Subsequent lncRNA functional characterization will in-volve the identification of interacting protein partners by affinity chromatography as well as over-expression or knockout of lncRNA genes by lentiviral gene transfer and CRISPR/Cas9 technology, followed by mRNA expression profiling. Furthermore, standard techniques in immunology and molecular biology (e.g. ELISA, real-time PCR) will be routinely applied.

Candidates should hold an excellent master or diploma degree in life sciences. A keen interest in current issues of Immunobiology and RNA biology is required as well as extensive practical experience with standard methods of eukaryote molecular biology. Previous experience with cell culture, RNA molecular biology and Infection biology are of advantage. Successful applicants can expect a state-of-the-art laboratory, an innovative research environment and excellent supervision.

For more information, please see http://www.i-lung.de/nwg or contact i-lung@uni-marburg.de.

We support women and strongly encourage them to apply. In areas where women are underrepre-sented, female applicants will be preferred in case of equal qualifications. Applicants with chil-dren are welcome – Philipps-University is certified as a family-friendly university. A reduction of working time is possible. Applicants with a disability as described in SGB IX (§ 2 Abs. 2, 3) will be preferred in case of equal qualifications.
As the documents will not be returned after end of the selection procedure, please do not send originals. Application and interview costs cannot be refunded.

Kontaktdaten


Art des Bewerbungszugangs
Please send a cover letter describing the research interest and qualifications, curriculum vitae including the university degrees and the contact information of two referees until 30.04.2015 in a single pdf file to i-lung@uni-marburg.de with reference number fb20-0062-wmz-2015.
Kontakt für Bewerbungen
Please send a cover letter describing the research interest and qualifications, curriculum vitae including the university degrees and the contact information of two referees until 30.04.2015 in a single pdf file to i-lung@uni-marburg.de with reference number fb20-0062-wmz-2015.

Details der Stellenanzeige


Arbeitszeit
Teilzeit
Vertragslaufzeit
Befristete Anstellung
Stellentyp
Promotionsstelle
Berufserfahrung
Berufserfahrung nicht vorausgesetzt
Region
Deutschland (Hessen)
Arbeitsort
35037 Marburg an der Lahn
Fachgebiet
Humanmedizin
JETZT BEWERBEN