PhD opportunity: computation and statistical genomics of gene network evolution in mammals
A PhD position in mammalian complex trait genomics is available in the Chan Lab at the Max Planck Institute in Tübingen, Germany as part of a Max Planck and ERC-funded research team investigating gene network evolution in mouse tissue culture models.
Your role: Your goal will be to understand the patterns and processes driving mammalian gene network evolution using in vitro crosses of tissue from interspecific mouse hybrids. You will work closely with a postdoc responsible for the derivation and generation of mouse recombinant inbred panels. You will be responsible for the generation, processing and analysis of DNA and RNAseq data to build detailed genotype-phenotype maps from in our “in vitro” crosses between interspecific mouse hybrids spanning increasing evolutionary divergence. You will link evolutionary changes in gene expression and phenotypes to specific genetic changes and identify general rules of mammalian gene network evolution. You will integrate into our broader research team and will have the opportunity to collaborate in many other exciting mapping and genomic studies (both intra- and interspecies) in mice and other vertebrates.
Requirements: You will have a Masters or equivalent degree, in Biostatistics, Bioinformatics or Statistical Genetics and in-depth research experience in these fields. You should demonstrate expertise and proficiency in handling large-scale computational data analyses, and advanced skills in statistical analysis (e.g. QTL or GWAS approaches, genotype imputation, Hidden Markov Models, and haplotype phasing of whole genome data). Experience with UNIX and fluency in statistical or programming languages (R and C++, Python or Perl) is essential. We are interested in candidates who are keen to apply new and innovative statistical approaches. Passion for research, team spirit and enthusiasm are essential.
Our Team: You will work in a multidisciplinary team that focuses on mammalian EvoDevo, combining population and comparative genomics with molecular biology and tissue engineering techniques to study the evolution of gene regulatory network in mouse and its close relatives. Our research group is funded by the European Research Council (ERC) and the Max Planck Society and is located on the Max Planck Campus in Tübingen, Germany. Tübingen is one of the best locations in the world in evolutionary genomics research. Our campus hosts world-class research groups, including a Nobel laureate and 11 other ERC-funded teams. We operate state-of-the-art sequencing and other core facilities. English is the working language. All seminars and communications are in English.
Our Offer: Funding is available for the duration of a PhD project (expected length: 3.5 years). Positions will supported by a scholarship contract with salary and benefits based on the German public service (TVöD) pay scale and are commensurate with training and experience.
The Max Planck Society seeks to increase the number of women in areas where they are underrepresented, and therefore explicitly encourages women to apply. The Max Planck Society is committed to employing more handicapped individuals and especially encourages them to apply.
To Apply: Consideration of applications will begin on July 1st 2015, and will remain open until filled. Please send your application with 1. a statement of research interests and why you have applied for this position, 2. your CV, and 3. three reference letters to Dr Frank Chan at email@example.com or the postal address below. Incomplete applications will not be considered.
Dr Frank Chan, Friedrich Miescher Laboratory of the Max Planck Society, Spemannstrasse 39, 72076 Tübingen, Germany.
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