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AG Puccetti

Institut für Molekularbiologie und Tumorforschung (IMT)

http://www.imt.uni-marburg.de/puccetti/index.php

Relevante Literatur:

Puccetti, E., Zheng, X., Brambilla, D., Seshire, A., Beissert, T., Boehrer, S., Nurnberger, H., Hoelzer, D., Ottmann, O.G., Nervi, C. and Ruthardt, M. (2005) The integrity of the charged pocket in the BTB/POZ domain is essential for the phenotype induced by the leukemia-associated t(11;17) fusion protein PLZF/RARalpha. Cancer Res, 65, 6080-6088.

Puccetti, E. and Ruthardt, M. (2004) Acute promyelocytic leukemia: PML/RARalpha and the leukemic stem cell. Leukemia, 18, 1169-1175.

Zheng, X., Beissert, T., Kukoc-Zivojnov, N., Puccetti, E., Altschmied, J., Strolz, C., Boehrer, S., Gul, H., Schneider, O., Ottmann, O.G., Hoelzer, D., Henschler, R. and Ruthardt, M. (2004) Gamma-catenin contributes to leukemogenesis induced by AML-associated translocation products by increasing the self-renewal of very primitive progenitor cells. Blood, 103, 3535-3543.

Puccetti, E., Beissert, T., Guller, S., Li, J.E., Hoelzer, D., Ottmann, O.G. and Ruthardt, M. (2003) Leukemia-associated translocation products able to activate RAS modify PML and render cells sensitive to arsenic-induced apoptosis. Oncogene, 22, 6900-6908.

Beissert, T., Puccetti, E., Bianchini, A., Guller, S., Boehrer, S., Hoelzer, D., Ottmann, O.G., Nervi, C. and Ruthardt, M. (2003) Targeting of the N-terminal coiled coil oligomerization interface of BCR interferes with the transformation potential of BCR-ABL and increases sensitivity to STI571. Blood, 102, 2985-2993.

Puccetti, E., Obradovic, D., Beissert, T., Bianchini, A., Washburn, B., Chiaradonna, F., Boehrer, S., Hoelzer, D., Ottmann, O.G., Pelicci, P.G., Nervi, C. and Ruthardt, M. (2002) AML-associated translocation products block vitamin D(3)-induced differentiation by sequestering the vitamin D(3) receptor. Cancer Res, 62, 7050-7058.

Puccetti, E., Sennewald, B., Fosca-Ferrara, F., Boehrer, S., Bianchini, A., Hoelzer, D., Ottmann, O.G., Nervi, C. and Ruthardt, M. (2001) Down-stream regions of the POZ-domain influence the interaction of the t(11;17)-associated PLZF/RARalpha fusion protein with the histone-deacetylase recruiting co-repressor complex. Hematol J, 2, 385-392.

Puccetti, E., Guller, S., Orleth, A., Bruggenolte, N., Hoelzer, D., Ottmann, O.G. and Ruthardt, M. (2000) BCR-ABL mediates arsenic trioxide-induced apoptosis independently of its aberrant kinase activity. Cancer Res, 60, 3409-3413.

Details


Adresse:
AG Puccetti
Institut für Molekularbiologie und Tumorforschung (IMT)
Emil-mannkopff-Str. 2
35033 Marburg
Deutschland
Arbeitsgebiet:
Forschung & Entwicklung
Forschung & Lehre
Expansion:
national