Collaborate Research Center 575/SFB 575
Due to their high morbidity and mortality liver diseases are of high interest with regard to socioeconomical implications. In Germany about one million human beings suffer from chronic liver disease, which include not only liver diseases triggered by virus infection, alcohol abuse and autoimmunity but increasingly liver diseases basing on an altered way of feeding in the civilized countries. Unfortunately a causal treatment of liver diseases is possible only in some cases (e.g. 40% success of interferon therapy of chronic virus hepatitis), however, liver damage, once occured, is barely reversible.
The aim of this Collaborative Research Center is to study normal liver function and the molecular mechanisms leading to clinical symptoms associated with liver injury. Basing on the results the rationale for new therapeutical strategies allowing more efficient treatment of liver diseases will be provided. A special focus is the investigation of intra- and intercellular communication mechanisms. This is highly topical because of increasing evidence that a dysregulation of signal transduction accounts for many diseases. The pharmacological interference with these processes is of high clinical relevance and this perspective gives the reasons for the persistent interest of this research association on this field.
In view of the complexity of liver architecture and function and the broad spectrum of acute and chronic liver diseases with manifold intra- and extrahepatic manifestations this Collaborative Research Center focuses on three subject areas:
A) metabolism and transport,
B) mechanisms of liver damage, and
C) pathogenesis of hepatic encephalopathy,
which all include the topics signal transduction and cross talk, protein modifications and the relevance of cell hydration for physiological and pathophysiological processes, cytoprotection and the regulation of gene expression. Likewise, all projects take advantage from a broad spectrum of imaging techniques (such as single cell fluorescence, confocal laser scanning microscopy, intravital fluorescence microscopy, fluorescence resonance energy transfer, magnet encephalography and positron emission tomography), which allow, together with other cell- and molecularbiological tools, integrative studies using experimental systems of increasing complexity.
- focus on signal transduction, cell hydration and cell function
- integrative studies on experimental systems of increasing complexity
- use of modern imaging techniques
pass through the whole Collaborative Research Center and guarantees manifold thematic and methodological interactions and an highly interdisciplinary treatment of hepatological topics.
Clinic for Gastroenterology, Hepatology, and Infectiology, Prof. Dr. Dieter Häussinger
Forschung & Lehre