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Heinrich-Heine-Universität Düsseldorf

Institut für physikalische Biologie

Mechanism of prion protein conversion and assembly Prion diseases are a unique group of neurodegenerative diseases because they are known to be transmissible. They can occur both spontaneously and genetically caused. During replication of the infectious agent, host encoded prion protein (PrP) is converted from its cellular isoform PrP C into the pathological and infectious isoform PrP Sc [1]. We investigated the conversion process by in vitro studies using recombinant PrP and natural PrP Sc . The results determined with our in vitro conversion system and the derived mechanistic models are presented as a brief summary. Furthermore, well characterized intermediates and precursor states during the conversion process as well as kinetic studies of spontaneous and seeded fibrillogenesis are described.

Details


Adresse:
Heinrich-Heine-Universität Düsseldorf
Institut für physikalische Biologie
Universitätsstr. 1
Geb. 26.12.U1
40225 Düsseldorf
Deutschland
Arbeitsgebiet:
Forschung & Lehre
Expansion:
national
Mitarbeiteranzahl:
11-50
Gründungsjahr:
1975